1. 毕业设计（论文）的内容和要求
本课题的任务是研究端炔与亚胺的加成反应 要求： 1、全面调研文献，在文献基础上要求设计出具有新颖性及可行性的合成方案； 2、研究方案确立以醛，胺为起始原料，制备丰富的亚胺衍生物，再和端炔衍生物在亚铜催化下进行加成反应，二氯甲烷等做溶剂。对反应时间，收率等因素进行探究。 3、在论文工作中，学生应严格遵守学校的作息时间，保证在规定时间内完成课题工作量。 |
2. 参考文献
[1] Deniel A. Black, Bruce A. Arndtsen. Copper-Catalyzed Coupling of Imines, Acid Chlorides, and Alkynes: A Multicomponent Route to Propargylamides[J]. Organic Letters, 2004, 6(7), 1107-1110. [2] Daniel A. Black, Ramsay E. Beveridge, Bruce A. Arndtsen. Copper-Catalyzed Coupling of Pyridines and Quinolines with Alkynes: A One-Step, Asymmetric Route to Functionalized Heterocycles[J]. J. Org. Chem, 2008, 73, 1906-1910. [3] Federica Colombo, Maurizio Benaglia, Simonetta Orlandi, et al. Very Mild, Enantioselective Synthesis of Propargylamines Catalyzed by Copper(I)-Bisimine Complexes[J]. J. Org. Chem, 2006, 71, 2064-2070. [4] Guillaume Magueur, Benoit Crousse, Daniele Bonnet-Delpon. Direct access to CF3-propargyl amines and conversion to difluoromethyl imines[J]. Tetrahedron Letters, 2005, 46, 2219-2221. [5] Hiroaki Ohno, Yusuke Ohta, Shinya Oishi, et al. Direct Synthesis of 2-(Aminomethyl)indoles through Copper(I)-Catalyzed Domino Three-Component Coupling and Cyclization Reactions[J]. Angew. Chem. 2007, 119, 2345-2348. [6] Nina Gommermann, Christopher Koradin, Kurt Polborn, et al. Enantioselective, Copper(I)-Catalyzed Three-Component Reaction for the Preparation of Propargylamines[J]. Angew. Chem. 2003, 42, 5763-5766. |
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