TYK2抑制剂的设计与合成任务书

 2021-10-17 18:52:56

1. 毕业设计（论文）的内容和要求

不同的JAK激酶家族成员负责介导不同细胞因子及其受体的信号。

TYK2与JAK2共同介导IL-12和IL-23的信号传导，与JAK1共同介导Ⅰ型干扰素。

所以将TYK2作为一个治疗自身免疫性疾病的一个靶点。

剩余内容已隐藏，您需要先支付后才能查看该篇文章全部内容！

2. 参考文献

[1] Efficacy and Safety of Tofacitinib in Subjects with Active Ankylosing Spondylitis (AS). ClinicalTrials.gov; U.S. National Institutes of Health: Bethesda, MD, 2018; [2] Tofacitinib for Inflammatory Eye Disease. ClinicalTrials.gov; U.S. National Institutes of Health: Bethesda, MD, 2018[3] Oral Tofacitinib in Adult Subjects with Discoid Lupus Erythematosus (DLE) and Systemic Lupus Erythematosus (SLE). ClinicalTrials.gov; U.S. National Institutes of Health: Bethesda, MD, 2017; [4] Evaluation of Tofacitinib in Early Diffuse Cutaneous Systemic Sclerosis (dcSSc) (TOFA-SSc). ClinicalTrials.gov; U.S. National Institutes of Health: Bethesda, MD, 2017; [5] Study of Tofacitinib in Refractory Dermatomyositis (STIR). ClinicalTrials.gov; U.S. National Institutes of Health: Bethesda, MD, 2016;[6] Hammare n, H. M.; Virtanen, A. T.; Raivola, J.; Silvennoinen, O. The Regulation of JAKs in Cytokine Signaling and its Breakdown in Disease. Cytokine 2019, 118, 48 63.

剩余内容已隐藏，您需要先支付 10元 才能查看该篇文章全部内容！立即支付

以上是毕业论文任务书，课题毕业论文、开题报告、外文翻译、程序设计、图纸设计等资料可联系客服协助查找。

您可能感兴趣的文章