1. 毕业设计（论文）的内容和要求
1．文献查阅掌握文献查阅的一般方法，学会使用计算机在中国期刊网，维普数据库，超星数字图书馆，Elsevier、NCBI电子期刊，Springer Link全文电子期刊，Web of Science等检索资源上查阅关于虫草素、长期毒性实验的相关文献。
2．文献阅读及综述阅读与虫草素、长期毒实验等相关的外文及中文文献，了解国内外的研究动态，撰写文献综述。
3．明确实验任务，拟定实验方案根据所查阅文献的内容，确定实验内容及方案，拟定科学可行的研究计划。
2. 参考文献
[1] Jin-Woo Jeong, Cheng-Yun Jin b, Gi-Young Kim c, Jae-Dong Lee, Cheol Park, Gun-Do Kim , Wun-Jae Kim, Won-Kyo Jung, Su Kil Seo. Anti-inflammatory effects of cordycepin via suppression of inflammatory mediators in BV2 microglial cells. International Immunopharmacology. 2010.10: 1580-1586.[2] Zhou, X., Meyer, C.U., Schmidtke, P., Zepp, F., Effect of cordycepin oninterleukin-10 production of human peripheral blood mononuclear cells.Eur. J. Pharmacol. 2002,453 (23): 309-317.[3] Koc, Y., Urbano, A.G., Sweeney, E.B., McCaffrey, R.. Induction of apoptosis by cordycepin in ADA-inhibited TdT-positive leukemia cells. Leukemia, 1996.10: 1019-1024.[4]Thomadaki H, Tsiapalis CM, Scorilas A. The effect of the polyadenylation inhibitor cordycepin on human Molt-4 and Daudi leukaemia and lymphoma cell lines. Cancer Chemother Pharmacol. 2008,61: 703-711.[5] Yun Y, Han S, Lee S, Ko SK, Lee C-k, Ha N-j, et al. Anti-diabetic effects of CCCA, CMESS, and Cordycepin from Cordyceps militaris and the immune responses in streptozotocin-induced diabetic mice. Nat Produc Sci. 2003,9: 291-298.[6] Won KJ, Lee SC, Lee CK, Lee HM, Lee SH, Fang Z, et al. Cordycepin attenuates neointimal formation by inhibiting reactive oxygen species-mediated responses in vascular smooth muscle cells in rats. J Pharmacol Sci. 2009,109: 403-412.[7] Li Y.,Li R.,Zhu S.,Zhou R., Wang L.,Du J.,Wang Y.,Zhou, B.,Mai, L. Cordycepin induces apoptosis and autophagy in human neuroblastoma SK-N-SH and BE (2)-M17 cells. Oncol. Lett. 2015, 9: 2541-2547.[8]Kim HG, hrestha B, Lim SY et al. Cordycepin inhibits lipopolysaccharide-inducedinflammation by the suppression of NF-kB through Akt and p38 inhibition in Raw264.7 macrophage cells. Eur J Pharmacol. 2006,545: 192-9.[9]Guo P,Kai Q,Gao J,Lian ZQ,Wu CM,Wu CA,etal. Cordycepin prevents hyperlipidemia in hamsters fed a high-fat diet via activation of AMP-activated protein kinase. J PharmacolSci. 2010,113: 395-403.[10]Wu C,Guo Y,Su Y,Zhang X,Luan H,Zhang X,etal.Cordycepin activates AMP-activated protein kinase(AMPK) via interaction with the gamma1subunit. J CellMolMed. 2014,18: 293-304.[11] Ma L,Zhang S,Du M.Cordycepinfrom Cordycepsmilitaris prevents hyperglycemia inalloxan-inducedndiabeticnmice. Nutr Res. 2015,35: 431-9.[12] Li X,Zhou Y,Zhang X,Cao X,Wu C,Guo P.Cordycepin stimulates autophagy in macrophages and prevents atherosclerotic plaque formation in ApoE-/-mice. Oncotarget. 2017,8: 94726-37.[13]Zhang P,Huang C,Fu C,Tian Y,Hu Y,Wang B,etal.Cordycepin (3'-deoxyadenosine) suppressed HMGA2,Twist1 and ZEB1-dependent melanoma invasion andmetastasis by targeting miR-33b.Oncotarget.2015,6: 9834-53.[14] Wong YY,Moon A,Duffin R,Barthet-Barateig A,Meijer HA,Clemens MJ,etal.Cordycep ininhibits protein synthesis and cell adhesion through effects on signal transduction. J BiolChem.2010,285: 2610-21.
以上是毕业论文任务书，课题毕业论文、开题报告、外文翻译、程序设计、图纸设计等资料可联系客服协助查找。
