1. 毕业设计(论文)的内容和要求
1、 毕业论文内容 氟代化合物在医药、农药和材料科学中发辉着越来越重要的作用,其中市场上的药品中,20%药物和35%农药中都含有氟原子。
传统的氟化反应发展于20世纪早期,氟化反应一般局限于一些简单的分子,而对于复杂化合物分子的特定位置的氟化反应比较困难。
传统的氟化反应可以构建芳基氟化物,如将苯胺类化合物可以转化为芳基氟化物的Balz-Schiemann反应和Halex 卤素交换反应。
2. 参考文献
[1] 陈发杰.钯-铜催化的2-2-吡啶基-异丙基胺导向的碳氢键官能团化反应研究[D].浙江大学,2016.[2] 徐筱.含氟有机物的合成研究[D].苏州大学,2018.[3] Joseph J M. Synthesis and Reactivity of 7-Azaindoles (1H-Pyrrolo(2,3-b)pyridine)(1H-Pyrrolo(2,3-b)pyridine)[J]. Current Organic Chemistry, 2001, 5(5): 471-506.[4] 张毅.基于C(sp~2)-H和C(sp~3)-H化学键官能团化的新合成方法研究[D].江西师范大学,2016.[5] Yamamuea, M.; Moritani, I.; Murahashi, S. J. Organomet. Chem, 1975, 91, 39.[6] 朱峰.C-F、C-N、C-S和C-H键的催化活化与转化[D].中国科学技术大学,2015.[7] Thibault C, Lheureux A, Bhide R S, et al. Concise and Efficient Synthesis of 4-Fluoro-1H-pyrrolo[2,3-b]pyridine[J]. Organic Letters, 2003, 5(26): 5023-5025.[8] Lal G S, Pez A G, Syvret R G, et al. ELECTROPHILIC NF FLUORINATING AGENTS[J]. Chemical Reviews, 1996, 96(5): 1737-1755.[9] Watson D A,Su M,Teverovskiy G,et al. Formation of ArF from LPdAr (F):Catalytic conversion of aryl triflates to aryl fluorides[J].Science, 2009, 325 (5948), 1661-1664.[10] 王法杰. NFSI类似物的合成及吲哚酮化合物的选择性氟化[D].华东理工大学,2014.[11] (a) Balz, G.; Schiemann, G. Ber. 1927, 60, 1186. (b) Milner, J. D.Synth. Commun. 1992, 22 (1), 73. (c) Laali K K, Gettwert V. Fluorodediazoniation in ionic liquid solvents: new life for the BalzSchiemann reaction[J]. Journal of Fluorine Chemistry, 2001, 107(1): 31-34.[12] Thibault C, Lheureux A, Bhide R S, et al. Concise and Efficient Synthesis of 4-Fluoro-1H-pyrrolo[2,3-b]pyridine[J]. Organic Letters, 2003, 5(26): 5023-5025.[13] (a) Differding E, Ofner H. N-Fluorobenzenesulfonimide: A Practical Reagent For Electrophilic Fluorinations[J]. Synlett, 1991, 1991(03): 187-189. (b) Barnes K D, Hu Y, Hunt D A, et al. Electrophilic Fluorination of a Highly Functionalized Pyrrole[J]. Synthetic Communications, 1994, 24(12): 1749-1755. (c) Zajc B.Synthesis of ()-trans-7,8-Dihydrodiol of 6-Fluoro-benzo[a]pyrene via Hydroxyl-Directed Regioselective Functionalization of Substituted Pyrene[J].Journal of Organic Chemistry, 1999, 64(6): 1902-1907.[14] Burnett, Duane A.; Bursavich, Matthew Gregory; Harrison, Bryce Alden Preparation of oxadiazine derivatives for use in the treatment of neurodegenerative diseases [J]PCT Int. Appl. 2017[15] Miao J, Yang K, Kurek M, et al. Palladium-Catalyzed Site-Selective Fluorination of Unactivated C(sp3)H Bonds[J]. Organic Letters, 2015, 17(15): 3738-3741.[16] Zhang Q., Yin X.-S., ChenK.,etal.StereoselectiveSynthesisofChiralβ-Fluoroα-AminoAcidsvia Pd(II)-CatalyzedFluorinationofUnactivatedMethyleneC(sp3)HBonds:Scopeand Mechanistic Studies [J]. Journal of the American Chemical Society, 2015, 137: 8219-8226. [17] Burnett, Duane A.; Bursavich, Matthew Gregory; Harrison, Bryce Alden Preparation of oxadiazine derivatives for use in the treatment of neurodegenerative diseases [J]PCT Int. Appl. 2017[18] Blake, James; Gunawardana, Indrani W.; Le Huerou, Yvan; Mohr, Peter J.; Wallace, Eli M.; Wang, BinPyrrolo[2,3-b]pyridines as CHK1 and CHK2 kinase inhibitors for the treatment of various diseases and preparation thereof2009[19] Hull K L, Anani W Q, Sanford M S, et al. Palladium-catalyzed fluorination of carbon-hydrogen bonds[J]. Journal of the American Chemical Society, 2006, 128(22): 7134-7135. [20] YandulovD.V.,TranN.T.Aryl-fluoridereductiveelimination from Pd(II): Feasibility aaassessmentfromtheoryandexperiment[J].JournaloftheAmericanChemicalSociety,2007, 129 (5): 1342-1358. [21] 刘娜.过渡金属催化构建C-F键和P-F键的研究[D].兰州大学,2016.
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