微流控芯片在药物分析中的应用及研究进展任务书

 2021-10-22 21:44:20

1. 毕业设计（论文）的内容和要求

课题简介微加工技术是制作衍射光学元件的主要技术之一，它利用强度可变的激光束对基片表面的抗蚀材料实施变剂量曝光，显影后便在抗蚀层表面形成要求的浮雕轮廓。

微流控芯片技术是把生物、化学、医学分析过程的样品制备、反应、分离、检测等基本操作单元集成到一块微米尺度的芯片上，自动完成分析全过程。

利用激光直写技术制作微流控芯片，不仅制作周期短且简便，而且制作的微流控芯片精度高，最终可应用于药物评价领域。

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2. 参考文献

1. Gao B , Liao J , Guo M , et al. Biomimetic Meta‐Structured Electro‐Microfluidics[J]. Advanced Functional Materials, 2019, 29(51).2. Elbaz A , He Z , Gao B , et al. Recent biomedical applications of bio-sourced materials[J]. 生物设计与制造, 2018, 1(1).3. Bingbing, Gao, Hong, et al. Flourishing Smart Flexible Membranes Beyond Paper.[J]. Analytical chemistry, 2019.4. Zhu X , Ju Y , Chen J , et al. Nonenzymatic Wearable Sensor for Electrochemical Analysisof Perspiration Glucose[J]. ACS Sensors, 2018, 3(6):1135-1141.5. Gao B , Elbaz A , He Z , et al. Bioinspired Kirigami Fish-Based Highly Stretched Wearable Biosensor for Human Biochemical-Physiological Hybrid Monitoring[J]. Advanced Materials Technologies, 2018.6. [, Bingbing, Gao, et al. Wearable eye health monitoring sensors based on peacock tail-inspired inverse opal carbon[J]. Sensors and Actuators B: Chemical, 2019.7. Disposable Morpho menelaus Based Flexible Microfluidic and Electronic Sensor for the Diagnosis of Neurodegenerative Disease8. Wang X , Gao B , Gu Z . Bioinspired transfer method for the patterning of multiple nanomaterials[J]. RSC Advances, 2019, 9(8):4351-4360.9. Wei, Li, Richard, et al. Rapidly separable microneedle patch for the sustained release of a contraceptive.[J]. Nature biomedical engineering, 2019.10. Seong K Y , Seo M S , Hwang D Y , et al. A self-adherent, bullet-shaped microneedle patch for controlled transdermal delivery of insulin[J]. Journal of Controlled Release, 2017, 265.

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