1. 毕业设计（论文）的内容和要求
生物骨组织替代用材料包括自体骨、异体骨和人工骨替代材料，以前人工骨替代材料往往采用不锈钢、铁合金和高分子材料。
但这些材料在生物体内长期植入后，不锈钢和铁合金存在溶析、腐蚀和疲劳问题；高分子材料会溶出制造时残留的未反应单体，对人体组织有一定的危害性，而且还存在稳定性差和强度低的问题。
因此世界各国相继发展了生物陶瓷材料，它不仅具有不锈钢塑料所具有的特性，而且具有亲水性、能与细胞等生物组织表现出良好的亲和性。
2. 参考文献
根据毕业要求指点2.3，毕设期间要进行研究现状调查与总结，要求在开题报告及毕业设计（论文）中涉及的参考文献不少于20篇，其中近5年不少于8篇，英文文献不少于5篇。
以下是与本课题相关的部分文献列表：（学生在此基础上，自行查阅补充）[1]Magdalna Precnerov, Katarna Bodiov,et al. In vitro bioactivity of silicon nitridehydroxyapatite composites[J]. Ceramics International, 2015, 41(6):8100-8108. [2] Jing Wang, Yu Zhu, et al. Fabrication and preliminary biological evaluation of a highly porous biphasic calcium phosphate scaold with nano-hydroxyapatite surface coating [J]. Acta biomaterialia, 2018, 44：13041311. [3] ZHANG R, MA P X. Porous poly(L‐lactic acid)/apatite composites created by biomimetic process [J]. Journal of Biomedical Materials Research, 2015, 45(4): 285-93.[4] 何春耒, 王大平, 马经野. 骨组织工程支架材料的种类及发展趋势 [J]. 中国组织工程研究, 2009, 13(25): 4905-8.[5] Qing F , Wang Z , Hong Y , et al. Selective effects of hydroxyapatite nanoparticles on osteosarcoma cells and osteoblasts[J]. Journal of Materials Science: Materials in Medicine, 2012, 23(9):2245-2251.[6] CC G E S, JR K B, CARBONARI M J, et al. Tissue response around silicon nitride implants in rabbits [J]. Journal of Biomedical Materials Research Part A, 2010, 84A(2): 337-43.[7] PEZZOTTI G, MCENTIRE B J, BOCK R, et al. Silicon Nitride: A Synthetic Mineral for Vertebrate Biology [J]. Scientific reports, 2016, 6(31717.[8] PEZZOTTI G, MARIN E, ADACHI T, et al. Bioactive silicon nitride: A new therapeutic material for osteoarthropathy [J]. Scientific reports, 2017, 7(44848.[9] BAL B S, RAHAMAN M N. Orthopedic applications of silicon nitride ceramics [J]. Acta biomaterialia, 2012, 8(8): 2889-98.[10] BODIOVK, KAIAROVM, DOMANICKM, et al. Porous silicon nitride ceramics designed for bone substitute applications [J]. Ceramics International, 2013, 39(7): 8355-62.[11] YIN L, ZHOU X, YU J, et al. Preparation of silicon nitride foam with three-dimensional interconnected pore structure [J]. Materials Design, 2016, 89(620-5.[12] Hong Y , Fan H , Li B , et al. Fabrication, biological effects, and medical applications of calcium phosphate nanoceramics[J]. Materials Science Engineering R: Reports, 2010, 70(3-6):225-242.[13] XU C, BAI Y, YANG S, et al. A versatile three-dimensional foam fabrication strategy for soft and hard tissue engineering [J]. Biomedical Materials, 2018, 13(2): 025018.[14] BODIOVK, KAIAROVM, VILCEKOVA Z, et al. Mechanical properties of macroporous silicon nitride-based ceramics designed for bone substitutes [J]. Ceramics Silikaty, 2014, 58(2): 99-105.[15] CHEN M, WANG C, WANG H, et al. Fabrication of hierarchically porous Si3N4 foam ceramics with stamen-like cell structure [J]. Materials Letters, 2014, 132(10): 119-22.
以上是毕业论文任务书，课题毕业论文、开题报告、外文翻译、程序设计、图纸设计等资料可联系客服协助查找。
