新型钯催化[1,2]-迁移反应方法学探索任务书

 2021-10-23 21:40:46

1. 毕业设计(论文)的内容和要求

1. 熟悉 Web of Sciense、Scifinder等检索工具的使用,学习文献检索技巧;锻炼英文文献阅读理解,完成一篇英文文献翻译。

2. 学习合成化学实验的过程,独立开展实验,结合实践加深对有机化学的理解。

3. 初步了解核磁,红外,HPLC,GC等常用分析仪器的原理及相关图谱解析,强化对实验结果的总结和分析能力,独立撰写学位论文。

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2. 参考文献

[1] Hongmiao Wu, Bin Yang, Lin Zhu, Ronghua Lu, Guigen Li, Hongjian Lu, High-Valent Palladium-Promoted Formal Wagner-Meerwein Rearrangement[J]. Organic Letters, 2016, 18(22): 5804~5807;[2] Topczewski, J. J., Sanford, M. S., Carbon-Hydrogen (C-H) Bond Activation at Pd(IV): A Frontier in C-H Functionalization Catalysis[J]. Chem. Sci. 2015, 6, 70;[3] P. Sehnal, R. J. K. Taylor, I. J. S. Fairlamb, Emergence of Palladium(IV) Chemistry in Synthesis and Catalysis[J]. Chem. Rev., 2010, 110, 824; [4] D. Kalyani, A. D. Satterfield, M. S. Sanford, Palladium-catalyzed oxidative arylhalogenation of alkenes: synthetic scope and mechanistic insights[J]. J. Am. Chem. Soc. 2010, 132, 8419;[5] Y. He, Z. Yang, R. T. Thornbury, F. D. Toste, Palladium-Catalyzed Enantioselective 1,1-Fluoroarylation of Aminoalkenes[J]. J. Am. Chem. Soc., 2015, 137, 12207;[6] X. Mu,; T. Wu, H. Wang, Y. Guo, G. Liu, Palladium-Catalyzed Oxidative Aryltrifluoromethylation of Activated Alkenes at Room Temperature[J]. J. Am. Chem. Soc. 2012, 134, 878;[7] C. F. Rosewall, P. A. Sibbald, D. V. Liskin, F. E. Michael, Palladium-catalyzed carboamination of alkenes promoted by N-fluorobenzenesulfonimide via C-H activation of arenes[J]. J. Am. Chem. Soc., 2009, 131, 9488;[8] A. Ulmer, C. Brunner, A. M. Arnold, A. Pthig T. Gulder, A Fluorination / Aryl Migration / Cyclization Cascade for the Metal-free Synthesis of Fluoro Benzoxazepines[J]. Chem. Eur. J. 2016, 22, 3660;[9] N. D. Ball, J. W. Kampf, M. S. Sanford, Aryl-CF3 Bond-Forming Reductive Elimination from Palladium(IV)[J]. J. Am. Chem. Soc. 2010, 132, 2878;[10] E. Lee, A. S. Kamlet, D. C. Powers, C. N. Neumann, G. B. Boursalian, T. Furuya, D. C. Choi, J. M. Hooker, T. Ritter, A Fluoride-Derived Electrophilic Late-Stage Fluorination Reagent for PET Imaging[J]. Science 2011, 334, 639;

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