1. 毕业设计（论文）的内容和要求
解析生物合成基因簇（如MIBiG库）论文，建立（针对靶向天然产物的）基因、基因簇、产物（结构、物性）的信息库。
2. 参考文献
1. van Santen, J.A., et al., The Natural Products Atlas: An Open Access Knowledge Base for Microbial Natural Products Discovery. ACS Cent Sci, 2019. 5(11): p. 1824-1833.2. Liu, Y., et al., Text mining biomedical literature for discovering gene-to-gene relationships: a comparative study of algorithms. IEEE/ACM Trans Comput Biol Bioinform, 2005. 2(1): p. 62-76.3. Kautsar, S.A., et al., MIBiG 2.0: a repository for biosynthetic gene clusters of known function. Nucleic Acids Res, 2020. 48(D1): p. D454-D458.4. Marcet-Houben, M. and T. Gabaldon, EvolClust: automated inference of evolutionary conserved gene clusters in eukaryotes. Bioinformatics, 2019.5. Navarro-Munoz, J.C., et al., A computational framework to explore large-scale biosynthetic diversity. Nat Chem Biol, 2020. 16(1): p. 60-68.6. Hannigan, G.D., et al., A deep learning genome-mining strategy for biosynthetic gene cluster prediction. Nucleic Acids Res, 2019. 47(18): p. e110.7. Liu, W., et al., BioC implementations in Go, Perl, Python and Ruby. Database (Oxford), 2014. 2014.
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