全文总字数：2054字
1. 毕业设计（论文）的内容和要求
关节软骨组织由于缺乏血管、神经、淋巴管的独特特性而使得其受损后自愈能力极其有限，长期以来都是医学领域中难以治愈的难题和挑战，软骨组织工程的出现则为临床上软骨缺损修复与再生开辟了新的方向。
在组织工程应用的支架材料中，可注射型水凝胶由于其高含水量、与天然细胞外基质（ECM）相似、具有适合细胞迁移和增殖的多孔三维网络结构、可微创注射操作和能够高度匹配任意缺损部位等优点，在软骨组织工程中具有广阔的应用前景。
然而，传统的水凝胶支架材料大多力学性能较差，仅能为细胞提供三维静态支撑作用，缺乏天然细胞外基质的功能性和智能响应性。
2. 实验内容和要求
制备性能优异的可注射聚氨基酸水凝胶，使其达到软骨修复支架材料的标准
3. 参考文献
1 Walker KJ, Madihally SV. Anisotropic temperature sensitive chitosan-based injectable hydrogels mimicking cartilage matrix. J Biomed MaterRes B Appl Biomater 2015; 103: 1149?160.2 S鰊tjens SHM, Nettles DL, Carnahan MA et al. Biodendrimer-basedhydrogel scaffolds for cartilage tissue repair. Biomacromolecules 2006; 7:310?16.3 Ren K, He C, Xiao C et al. Injectable glycopolypeptide hydrogels asbiomimetic scaffolds for cartilage tissue engineering. Biomaterials 2015;51: 238?49.4 Cancedda R, Dozin B, Giannoni P et al. Tissue engineering and celltherapy of cartilage and bone. Matrix Biol 2003; 22: 81?1.5 Hjelle K, Solheim E, Strand T et al. Articular cartilage defects in 1,000knee arthroscopies. Arthroscopy 2002; 18: 730?34.6 Vilela CA, Correia C, Oliveira JM et al. Cartilage repair using hydro-gels: a critical review of in vivo experimental designs. ACS Biomater SciEng 2015; 1: 726?39.7 Liao J, Shi K, Ding Q et al. Recent developments in scaffold-guidedcartilage tissue regeneration. J Biomed Nanotechnol 2014; 10: 3085?104.8 Yuan T, Zhang L, Li K et al. Collagen hydrogel as an immunomodu-latory scaffold in cartilage tissue engineering. J Biomed Mater Res B ApplBiomater 2014; 102: 337?44.9 Buckwalter J. Articular cartilage: injuries and potential for healing.J Orthop Sports Phys Ther 1998; 28: 192?02.10 Huey DJ, Hu JC, Athanasiou KA. Unlike bone, cartilage regenerationremains elusive. Science 2012; 338: 917?21.
4. 毕业设计（论文）计划
1. 2020.12-2021.1 文献调研及路线设计；2. 2021.2-2021.5 实验合成及工艺路线优化； 3. 2021.6 数据整理及论文写作。
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