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1. 毕业设计（论文）的内容和要求
Liver is an essential organ in the human body as it performs many functions. The liver malfunction can be caused by factors such as alcohol consumption and obesity, viral infection or adverse reaction to drugs. Damage to the liver can be both asymptomatic and symptomatic.Severe scarring of the tissue (cirrhosis) can lead to liver cancer.Some acute liver failures can be cured and others cannot be cured. Non-alcoholic liver failure, if detected early, may be cured by medication and changes in the life style. In this review, the role and regulatory mechanism of the key early warning biomarker in HBx-induced liver fibrosis/cirrhosis transformation will be discussed.
2. 实验内容和要求
No less than two months full-time work in this project.Submit weekly report and write final thesis.
3. 参考文献
1. Kanai F,Marignani P A,Sarbassova D et al. TAZ: a novel transcriptional co-activator regulated by interactions with 14-3-3 and PDZ domain proteins.[J] .EMBO J., 2000, 19: 6778-91.2.Sudol M. Yes-associated protein (YAP65) is a proline-rich phosphoprotein that binds to the SH3 domain of the Yes proto-oncogene product[j].Oncogene. 1994 Aug;9(8):2145-52.3. Sudol M,Bork P,Einbond A et al. Characterization of the mammalian YAP (Yes-associated protein) gene and its role in defining a novel protein module, the WW domain.[J] .J. Biol. Chem., 1995, 270: 14733-41.4.Pan D. The Hippo signaling pathway in development and cancer[J]. Dev Cell., 2010, 19: 491505.
4. 毕业设计（论文）计划
2021.03-2021.04 Literatures searching;2021.04-2021.06 Analyzing the information and write the review;2021.06 Submit the final thesis and finish defense.
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