全文总字数：1823字
1. 毕业设计（论文）的内容和要求
Talin-1 is a large cytoskeletal dimeric adaptor protein that associates with the integrin family of cell adhesion molecules in cell-ECM junctions. It both activates integrins and couples them to the actin cytoskeleton. It has been reported to be accused in the cancer progression and metastasis. Talin-1 was studied as biomarker for process of the carcinogenesis, infiltration and metastasis of HCC and the clinical diagnosis of HCC. In our proteomics data, talin-1 has been identified to changes significantly in liver disease development, however, its detail role in this process is unclear. In this study, we will analyze or summarize the function of talin-1 in transition of liver fibrosis to cirrhosis and analyze the proteomics data focus on talin-1.
2. 实验内容和要求
(1) Search literatures and summarize the function of talin-1.(2) Submit a review of talin-1.(3) Analyze the proteomics data.
3. 参考文献
1. Lin KC, Park HW, Guan KL. Regulation of the Hippo Pathway Transcription Factor TEAD[J].Trends Biochem Sci,2017,42(11):862-872.2.Yi Jing,Lu Li,Yanger Kilangsungla et al. Large tumor suppressor homologs 1 and 2 regulate mouse liver progenitor cell proliferation and maturation through antagonism of the coactivators YAP and TAZ. [J]. Hepatology, 2016, 64: 1757-1772.3.Wang X D, Andersson R, Soltesz V et al. Phospholipids prevent enteric bacterial translocation in the early stage of experimental acute liver failure in the rat.[J] .Scand. J. Gastroenterol., 1994, 29: 1117-21.4. Mauviel A,Nallet-Staub F,Varelas X,Integrating developmental signals: a Hippo in the (path)way.[J] .Oncogene, 2012, 31: 1743-56.
4. 毕业设计（论文）计划
2021.3-2021.4 Search information to understand the project;2021.4-2021.6 Write the review and finish final defense.
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