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1. 毕业设计（论文）的内容和要求
1、毕业论文内容生物催化和固体酸/碱是绿色合成化学的重要研究内容，一锅法多组分缩合反应在杂环化合物合成中具有重要的研究价值和实际应用。
苯并吡喃类化合物因其具有广泛的生理和药理活性，受到了广大研究者的关注。
目前，合成苯并吡喃衍生物的方法多种多样，比如酒石酸钾钠催化，有机碱催化，沸石催化，离子液体催化，纳米粒子催化，微波辐射等。
2. 实验内容和要求
1、实验内容（1）合成目标产物并建立产物的液相色谱分析方法。
（2）对脂肪酶种类进行筛选。
（3）对固体酸催化剂的催化性能进行考察。
3. 参考文献
1. Ding Y, Huang H, Hu Y, et al. New progress on lipases catalyzed C-C bond formation reactions[J]. Chinese Journal of Organic Chemistry, 2013, 33 (5): 905-914.2. Lopez-Iglesias M, Gotor-Fernandez V. Recent advances in biocatalytic promiscuity: hydrolase-catalyzed reactions for nonconventional transformations[J]. Chemical Record, 2015, 15 (4): 743-759.3. Miao Y, Rahimi M, Geertsema E M, Poelarends G J, et al. Recent developments in enzyme promiscuity for carbon-carbon bond-forming reactions[J]. Current Opinion in Chemical Biology, 2015, 25, 115-123.4. Abbaspour-Gilandeh E, Aghaei-Hashjin M, Yahyazadeh A, et al. (CTA)3[SiW12]Li MMT: a novel, efficient and simple nanocatalyst for facile and one-pot access to diverse and densely functionalized 2-amino-4H-chromene derivatives via an eco-friendly multicomponent reaction in water[J]. RSC Advances, 2016, 6 (60): 55444-55462.5. Sedaghat M E, Rajabpour Booshehri M, Nazarifar M R, et al. Surfactant modified bentonite (CTMAB-bentonite) as a solid heterogeneous catalyst for the rapid synthesis of 3,4-dihydropyrano[c]chromene derivatives[J]. Applied Clay Science, 2014, 95, 55-59. 6. Nagalapalli R, Jaggavarapu S R, Jalli V P, et al. Ultrasound promoted green and facile one-pot multicomponent synthesis of 3,4-dihydropyrano[c]chromene derivatives[J]. Journal of Chemistry, 2013, 2013, 1-8.7. Kanakaraju S, Prasanna B, Basavoju S, et al. Ammonium acetate catalyzed an efficient one-pot three component synthesis of pyrano[3,2-c]chromene derivatives[J]. Arabian Journal of Chemistry, 2017, 10, S2705-S2713.8. Azizi K, Heydari A. A simple, green, one-pot synthesis of magnetic-nanoparticle-supported proline without any source of supplemental linkers and application as a highly efficient base catalyst[J]. RSC Advances, 2014, 4 (13): 6508-6512.9. Khan T, Siddiqui Z N. Perchloric acid modified-cellulose: a versatile, novel and biodegradable heterogeneous solid acid catalyst for single-pot synthesis of novel bis-pyran annulated heterocyclic scaffolds under solvent-free conditions[J]. New Journal of Chemistry, 2014, 38 (10): 4847-4858.10. Tabatabaeian K, Zanjanchi M A, Mamaghani M, et al. Anchoring of ruthenium onto imine-functionalized zeolite beta: an efficient route for the synthesis of 4H-benzo[b]pyrans and pyrano[c]chromenes[J]. Canadian Journal of Chemistry 2014, 92 (11): 1086-1091.11. Mayank, Kaur Billin B, Agnihotri P K, et al. Ionic liquid-coated carbon nanotubes as efficient metal-free catalysts for the synthesis of chromene derivatives[J]. ACS Sustainable Chemistry Engineering, 2018, 6 (3): 3714-3722.12. Dekamin M G, Eslami M, Maleki A. Potassium phthalimide-N-oxyl: a novel, efficient, and simple organocatalyst for the one-pot three-component synthesis of various 2-amino-4H-chromene derivatives in water[J]. Tetrahedron, 2013, 69 (3): 1074-1085.13. Brahmachari G, Laskar S, Banerjee B. Eco-friendly, one-pot multicomponent synthesis of pyran annulated heterocyclic scaffolds at room temperature using ammonium or sodium formate as non-toxic catalyst[J]. Journal of Heterocyclic Chemistry, 2014, 51 (S1): E303-E308.14. Esmaeilpour M, Javidi J, Dehghani F, et al. A green one-pot three-component synthesis of tetrahydrobenzo[b]pyran and 3,4-dihydropyrano[c]chromene derivatives using a Fe3O4@SiO2imidPMAn magnetic nanocatalyst under ultrasonic irradiation or reflux conditions[J]. RSC Advances, 2015, 5 (34): 26625-26633.15. Fu Y. J., Lu Z. P., Fang K.,et al. Enzymatic approach to cascade synthesis of bis(indolyl)methanes in pure water[J]. RSC Advances, 2020, 10, 10848-10853.16. Fu Y. J., Lu Z. P., Fang K., Xinyi He, et al. Promiscuous enzyme-catalyzed cascade reaction in water: Synthesis of dicoumarol derivatives. Bioorganic Medicinal Chemistry Letters[J]. 2019, 29(10): 1236-1240.17. Fu Y. J., Fan B. B., Chen H. Y., et al. Promiscuous enzyme-catalyzed cascade reaction: synthesis of xanthone derivatives[J]. Bioorganic Chemistry, 2018, 80, 555-559.18. Fu Y. J., Lu Z. P., Ma X. L., et al. One-pot cascade synthesis of benzopyrans and dihydropyrano[c]chromenes catalyzed by lipase TLIM[J]. Bioorganic Chemistry, 2020, 10388.
4. 毕业设计（论文）计划
起讫日期 设计（论文）各阶段工作内容备 注2021.01-2021.02 完成文献检索和开题报告 2021.02-2021.03 建立HPLC分析方法，对实验室现有的几种脂肪酶进行筛选 2021.04-2021.05 对固体酸催化剂进行催化性能考察 2021.05-2021.06 对底物进行扩展；得到分离产物；催化剂重复性能考察2021.06 数据整理、论文写作和答辩
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