1. 1. 毕业设计（论文）的内容、要求、设计方案、规划等
研究内容：通过Discovery studio 3.1中的3D-QSAR(定量构效关系)对4-氨基喹唑啉衍生物的活性经行评价，并通过docking筛选出一批具有潜在活性的小分子。
本课题需要具有
1. 较强的动手能力和不懈的毅力；
2. 参考文献（不低于12篇）
1. Jia-Jia Liu, Hui Zhang, Juan Sun, Zhong-Chang Wang, Yu-Shun Yang, Dong-Dong Li, Fei Zhang, Hai-Bin Gong, Hai-Liang Zhu*, Synthesis, biological evaluation of novel 4,5-dihydro-2H-pyrazole 2-hydroxyphenyl derivatives as BRAF inhibitors, Bioorg. Med. Chem. 2012, 20, 6089-6096.
2. Yu-Shun Yang, Qing-Shan Li, Shuai Sun, Yan-Bin Zhang, Xiao-Liang Wang, Fei Zhang, Jian-Feng Tang, Hai-Liang Zhu*, Design, modification and 3D QSAR studies of novel 2,3-dihydrobenzo[b][1,4]dioxin-containing 4,5-dihydro-1H-pyrazole derivatives as inhibitors of B-Raf kinase, Bioorg. Med. Chem. 2012, 20, 6048-6058.
3. Yin Luo, Li-Rong Zhang, Yang Hu, Shuai Zhang, Jie Fu, Xiao-Ming Wang, Hai-Liang Zhu*, Synthesis and Antimicrobial Activities of Oximes Derived from O-Benzylhydroxylamine as FabH Inhibitors, ChemMedChem, 2012, 7, 1587-1593.
以上是毕业论文任务书，课题毕业论文、开题报告、外文翻译、程序设计、图纸设计等资料可联系客服协助查找。
