1. 毕业设计（论文）的内容和要求
本课题将设计构建一种以嵌段共聚物聚氧乙烯-聚氧丙烯-聚氧乙烯(PEO-PPO-PEO)和树形多肽聚赖氨酸为原料，基于Pluronics F127水溶液体系的胶束化和凝胶化作用的，并具有pH和温度双重响应性能的水凝胶材料。
通过对Pluronics F127进行醛基功能化修饰，为与聚赖氨酸的氨基进行动态共价键交联提供了位点；通过Pluronics F127水溶液体系的胶束化，为水凝胶体系提供规整的疏水区，也将醛基位点曝露于胶束的外部；结合动态共价键交联、胶束化作用和疏水作用，在赋予水凝胶pH和温度响应性的同时，也增加了水凝胶的稳定性。
在成功构建水凝胶的基础上，进一步研究水凝胶的环境响应性能。
2. 参考文献
根据毕业要求指点10.2，毕设期间要进行研究现状调查与总结，要求在开题报告及毕业设计（论文）中涉及的英文文献不少于20篇，其中近5年不少于8篇，英文文献不少于5篇。
以下是与本课题相关的部分文献列表：[1] Jin Qu, Xin Zhao, Yongping Liang, Tianlong Zhang, Peter X. Ma,Baolin Guo. Antibacterial adhesive injectable hydrogels with rapid self-healing, extensibility and compressibility as wound dressing for joints skin wound healing. Biomaterials 183 (2018) 185-199.[2] Ziyi Li, Fei Zhou, Zhiyong Li, Siyu Lin, Lei Chen, Lixin Liu, and Yongming Chen. Hydrogel Cross-Linked with Dynamic Covalent Bonding and Micellization for Promoting Burn Wound Healing. ACS Appl. Mater. Interfaces 2018, 10, 25194-25202.[3] Huaping Tan, Constance R. Chu, Karin A. Payne, Kacey G. Marra. Injectable in situ forming biodegradable chitosanhyaluronic acid based hydrogels for cartilage tissue engineering. Biomaterials 30 (2009) 2499-2506.[4] Qiutong Huang, Yijie Zou, Maria C. Arno, Shuai Chen, Tao Wang, Jingyi Gao, Andrew P. Dove and Jianzhong Du. Hydrogel scaffolds for differentiation of adipose-derived stem cells. Chem. Soc. Rev. 2017, 46, 6255-6275.[5] Haofang Zhu, Xiaojun Cai, Lihuang Wu and Zhongwei Gu. A facile one-step gelation approach simultaneously combining physical and chemical cross-linking for the preparation of injectable hydrogels. J. Mater. Chem. B, 2017, 5, 3145-3153.[6] Wang D K, Varanasi S, Strounina E, et al. Synthesis and Characterization of a POSS-PEG Macromonomer and POSS-PEG-PLA Hydrogels for Periodontal Applications[J]. Biomacromolecules, 2014, 15(2):666-679.[7] Alexandridis P, Athanassiou V, Hatton T A. Pluronic-P105 PEO-PPO-PEO Block Copolymer in Aqueous Urea Solutions: Micelle Formation, Structure, and Microenvironment[J]. Langmuir, 1995, 11(7):2442-2450.[8] Desai P R, Jain N J, Sharma R K, et al. Effect of additives on the micellization of PEO/PPO/PEO block copolymer F127 in aqueous solution[J]. Colloids and Surfaces A Physicochemical and Engineering Aspects, 2001, 178(1-3):57-69.[9] Bu Y Z, Sun G F, Zhang L C, et al. POSS-modified PEG adhesives for wound closure[J]. Chinese Journal of Polymer Science, 2017, 35(10):1231-1242.[10] Kuo S W, Chang F C. POSS related polymer nan-ocomposites[J]. Progress in Polymer Science, 2011, 36(12):1649-1696.[11] Rao C, Tam J P. Synthesis of Peptide Dendrimer[J]. Journal of the American Chemical Society, 1994, 116(15):6975-6976.[12] Moore T, Croy S, Mallapragada S, et al. Experimental investigation and mathematical modeling of Pluronic F127 gel dissolution: Drug release in stirred systems[J]. Journal of Controlled Release, 2000, 67(2-3):191-202.[13] Ye F, Yaghmur A, Jensen H, et al. Real-time UV imaging of drug diffusion and release from Pluronic F127 hydrogels[J]. European Journal of Pharmaceutical Sciences, 2011, 43(4):236-243.[14] Pu Y, Zhang L, Zheng H, et al. Drug release of pH-sensitive poly(L-aspartate)-b-poly(ethylene glycol) micelles with POSS cores[J]. Polymer Chemistry, 2013, 5.[15] Ma J H, Guo C, Tang Y L, et al. 1 H NMR Spectroscopic Investigations on the Micellization and Gelation of PEO-PPO-PEO Block Copolymers in Aqueous Solutions[J]. Langmuir, 2007, 23(19):9596-9605.[16] 徐晖. 聚甲基丙烯酸泊洛沙姆水凝胶的研究[D]. 沈阳药科大学, 2001.[17] 曾志鹏. 刺激响应纳米药物载体的制备及其控释特性研究[D]. 南昌大学, 2014.[18] 程冬玲. 树状大分子PAMAM的合成、表征和阻垢性能研究[D]. 中国石油大学, 2009.[19] 毕继安, 杜立波, 高艳丽, et al. 树枝状大分子(PAMAM)的合成与表征及端基分析[J]. 贵州师范大学学报(自然科学版), 2013, 31(3):76-78.[20] 高春梅, 柳明珠, 吕少瑜. 荧光性树枝状分子:从单分子胶束到可注射水凝胶[C]. 2015年全国高分子学术论文报告会.
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