1. 毕业设计（论文）主要目标：
1．解析扬州地区PM2.5中重金属污染特征（浓度水平、元素组成等）。2．比较PM2.5中重金属在四种不同生物模拟液（模拟肺液、模拟胃液、人工汗液、PBS缓冲液）中的萃取效率，并探索原因。
2. 毕业设计（论文）主要内容：
本项目选择地处长三角区域，江淮平原南端的扬州，收集当地大气细颗粒物，并研究其中重金属的组成和浓度水平，比较PM2.5中重金属在四种不同生物模拟液（模拟肺液、模拟胃液、人工汗液、PBS缓冲液）中的萃取效率，探索萃取率差异的原因，揭示PM2.5主要的人体暴露途径。
为区域健康风险评价，健康防护措施的制定提供科学依据。
3. 主要参考文献
[1] Hu X, Zhang Y, Ding Z, et al. Bioaccessibility and health risk of arsenic and heavy metals (Cd, Co, Cr, Cu, Ni, Pb, Zn and Mn) in TSP and PM2.5 in Nanjing, China[J]. Atmospheric Environment, 2012, 57(57):146-152.[2] Huang X, Betha R, Tan L Y, et al. Risk assessment of bioaccessible trace elements in smoke haze aerosols versus urban aerosols using simulated lung fluids[J]. Atmospheric Environment, 2015.[3] Zereini F, Wiseman C L, Pttmann W. In vitro investigations of platinum, palladium, and rhodium mobility in urban airborne particulate matter (PM10, PM2.5, and PM1) using simulated lung fluids.[J]. Environmental Science Technology, 2012, 46(18):10326-10333.[4] Birmili W, Allen A G, Bary F, et al. Trace metal concentrations and water solubility in size-fractionated atmospheric particles and influence of road traffic.[J]. Environmental Science Technology, 2006, 40(4):1144-1153.[5] Sun L, Wu Q, Liao K, et al. Contribution of heavy metals to toxicity of coal combustion related fine particulate matter (PM2.5) in Caenorhabditis elegans with wild-type or susceptible genetic background.[J]. Chemosphere, 2016, 144:2392-2400.[6] Charrier J G, Anastasio C. Impacts of antioxidants on hydroxyl radical production from individual and mixed transition metals in a surrogate lung fluid[J]. Atmospheric Environment, 2011, 45(40):7555-7562.
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