1. 1. 毕业设计（论文）的内容、要求、设计方案、规划等
研究内容：4-氨基喹唑啉衍生物的活性经行评价，并通过docking筛选出一批具有潜在活性的小分子，预测结果是喹唑啉的1,4号位的N能具有与EGFR（1M17,from pdb蛋白数据库），VEGFR （4ASE，from pdb 蛋白数据库）发生相互作用关系。
1. 较强的动手能力和不懈的毅力；
2. 由于本课题所含内容较多，故需学生扎实地在实验室做实验。
2. 参考文献（不低于12篇）
1. Qing-Shan Li, Peng-Cheng Lv, Huan-Qiu Li, Xiang Lu, Zi-Lin Li, Ban-Feng Ruan, Hai-Liang Zhu*, Synthesis and biological evaluation of novel N, N′-disubstituted urea and thiourea derivatives as potential anti-melanoma agents, J. Enzym. Inhibit. Med. Chem. 2012, 27(5), 708-714.
2. Xi-Shou Huang, Kai Liu, Yong Yin, Wan-Mei Li, Wei Ran, Man Duan, Li-Sheng Wang, Hai-Liang Zhu*, The synthesis, structure and activity evaluation of secnidazole derivatives as Helicobacter pylori urease inhibitors, Curr. Bioact. Compds., 2011, 7, 268-280.
3. Hong-Jia Zhang, Xuan Qin, Kai Liu, Di-Di Zhu, Xiao-Ming Wang, Hai-Liang Zhu*, Synthesis, antibacterial activities and molecular docking studies of Schiff bases derived from N-(2/4-benzaldehyde-amino)phenyl-N0-phenyl-thiourea, Bioorg. Med. Chem. 2011, 19, 5708-5715.
以上是毕业论文任务书，课题毕业论文、开题报告、外文翻译、程序设计、图纸设计等资料可联系客服协助查找。
