以生物法制备的γ-聚谷氨酸为基的纳米水凝胶的制备任务书

 2021-09-30 22:48:18

1. 毕业设计(论文)的内容和要求

聚谷氨酸(PGA)是一类常用的生物降解高分子,具有对生物体无毒,无副作用,无免疫原性,并且还具有良好的生物相容性,早在20世纪70年代就有人合成了聚谷氨酸,并将其作为药物载体材料进行研究。

γ-多聚谷氨酸(γ-poly glutamic acid,γ-PGA)是一种由多种杆菌合成并分泌到细胞外的水溶性高分子量氨基酸聚合物,由D-谷氨酸和L-谷氨酸通过γ-谷氨酰键聚合而成。

水凝胶是亲水的聚合物网络,具有高吸水性、较高的机械强度、降解可控性和生物相容性,是一种制备创伤敷料和组织工程支架的理想材料。

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2. 参考文献

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