1. 毕业设计（论文）的内容和要求
内容和要求1.文献查阅学会利用计算机在中国期刊网、维普数据网、Springerlink、CA、SCI、Elsevier等等网络检索资源上检索、查阅与二氢乳清酸酶及其应用相关的文献，掌握文献查阅的方法。
2.文献阅读及综述仔细阅读与所做课题相关的国内外文献，了解相关的背景知识以及目前国内外的研究动态，会系统分析，撰写文献综述。
3.明确实验任务，拟定实验方案根据所查文献的内容，结合大学所学课程相关知识，确定实验内容及方案，拟定科学可行的研究计划。
2. 参考文献
[1] Hans Fischer (1943). "2,4-Dimethyl-3,5-dicarbethoxypyrrole". Org. Synth.; Coll. Vol. 2: 202.[2] Hans Fischer (1955). "Kryptopyrrole". Org. Synth.; Coll. Vol. 3: 513.[3] W. L. Semon and V. R. Damerell (1943). "Dimethoxyglyoxime". Org. Synth.; Coll. Vol. 2: 204.[4] Walter H. Hartung and Frank Crossley (1943). "Isonitrosopropiophenone". Org. Synth.; Coll. Vol. 2: 363. [5] Nathan Levin and Walter H. Hartung (1955). "ω-chloroisonitrosoacetophenone". Org. Synth.; Coll. Vol. = 3: 191.[6] J. P. Ferris, R. A. Sanchez, and R. W. Mancuso (1973). "p-toluenesulfonate". Org. Synth.; Coll. Vol. 5: 32.[7] 刘萍，乳腺癌药物研究进展，国外医药 合成药、生化药、制剂分册，1999，20(1): 6[8] 张炜帧，叶酸拮抗剂PT523的合成研究[D]，天津大学化工学院，2008[9] Camiue G, Wermuth. The practice of medicinal chemistry [J]. America: Academic press, 2003, 323~324.[10] Sigrid H, Erik DC, Balzarini J. Role of antimetabolites of purine and pyrimidine nucleotide metabolism in tumor cell differentiation [J]. Biochem Pharmaco. 1999, 58: 539~555.[11] Krug, Lee M, Kenneth K, Kris, Mark G, et al. Phase I and pharmacokinetic study of 10-propargyl-10-deazaaminopterin, a new antifolate [J]. Clinical Cancer Research. 2001,7: 1103.[12] Wang, Eunice S.; O'Connor, Owen; Sirotnak, F M, et al. Activity of a Novel Antifolate (PDX, 10-propargyl 10-deazaaminopterin) against Human Lymphoma is Superior to Methotrexate and Correlates with Tumor RFC-1 Gene Expression [J]. Leukemia Lymphoma. 2003, 44: 1027~1035.[13] Jones T R, Calvert A H, Jackman A L. A potent antitumor quinazoline inhibitor of thymidylate synthetase synthesis, biological properties and therapeuticresulta in mice [J]. Eur J Cancer 1981, 17：11~19.[14] 夏青，李仁利，叶酸拮抗剂的研究概况，国外医药合成药、生化药、药剂分册，1997，18(3): 135~140.[15] Jones T R, Thornton T J, Flinn A, et al. Quinazoline antifoltan inhibiting thymidylate synthase: 2-Desamino derivatives with enhanced solubility and potency [J]. J Med Chem. 1989, 32：847~852.[16] Hughes L R, Jackman A L, Oldfield J, et al. Quinezoline antifolate thymidylate synthase inhibitors: Alkyl, substituted alkyl and aryl substituents in the C2 position [J]. J Med Chem. 1990, 33: 3060~3067.[17] Piper J R, McCaleb G S, Montgomery J A, et al.10-Propargylaminopterin and alkyl homologues of methotrexate as inhibitors of folate metabolism [J]. J hied Chem. 1982, 26：877~880.[18] Piper J R, Montgomery J A, Sirotnak F M, Synthesis and antifolate propertiee of 5-alkyl-5-deazaaminopterin analogues modified in the l0-position [J]. Chemistry and Biology of Pteridines. 1990, 1039~1042.[19] O'Connor, Owen A. Pralatrexate: an emerging new agent with activity in T-cell lymphomas [J].Current Opinion in Oncology. 2006 ,18: 591~597.[20] Cheson, Bruce D. Novel therapies for peripheral T-cell non-Hodgkin's lymphomas. [J]. Current Opinion in Hematology .2009, 16: 299~305.
以上是毕业论文任务书，课题毕业论文、开题报告、外文翻译、程序设计、图纸设计等资料可联系客服协助查找。
