小鼠UVB损伤皮肤组织恢复过程免疫应答模型构建：Alloferon扰动分析任务书

 2021-11-03 22:43:38

1. 毕业设计（论文）的内容和要求

1、完成UVB晒伤小鼠皮肤组织恢复的Alloferon对照转录组学实验。

2. 构建小鼠皮肤细通晒伤恢复过程的免疫应答通路统计模型。

3. 构建本地化的转录组学分析平台4. 分析转录组学数据、构建alloferon对免疫应答通路的扰动模型。

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2. 参考文献

1. Kim, Y., et al., The anti-inflammatory effect of alloferon on UVB-induced skin inflammation through the down-regulation of pro-inflammatory cytokines. Immunol Lett, 2013. 149(1-2): p. 110-8.2. Ryu, M.J., et al., Activation of NF-kappaB by alloferon through down-regulation of antioxidant proteins and IkappaBalpha. Mol Cell Biochem, 2008. 313(1-2): p. 91-102.3. Czarniewska, E., et al., The long-term immunological effects of alloferon and its analogues in the mealworm Tenebrio molitor. Insect Sci, 2018. 25(3): p. 429-438.4. Mahlapuu, M., et al., Antimicrobial Peptides: An Emerging Category of Therapeutic Agents. Front Cell Infect Microbiol, 2016. 6: p. 194.5. Quaresma, J.A.S., Organization of the Skin Immune System and Compartmentalized Immune Responses in Infectious Diseases. Clin Microbiol Rev, 2019. 32(4).6. Nguyen, A.V. and A.M. Soulika, The Dynamics of the Skin's Immune System. Int J Mol Sci, 2019. 20(8).7. Haas, B.J., et al., De novo transcript sequence reconstruction from RNA-seq using the Trinity platform for reference generation and analysis. Nat Protoc, 2013. 8(8): p. 1494-512.8. Jeon, J., et al., Anti-inflammatory Effect of Alloferon on Ovalbumin-induced Asthma. Immune Network, 2015. 15(6): p. 304-12.

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