1. 毕业设计（论文）的内容和要求
1. 完成酵母菌T. mycotoxinivorans全基因组测序2. 搭建适合各类真菌体系的全基因组注释平台3. 构建酶结构建模与分子对接的生信模拟系统4. 利用注释平台和模拟系统，完成酵母菌T. mycotoxinivorans的全基因组功能注释，筛查玉米赤霉烯酮生物降解基因，给出相应的降解途径5. 完成论文及平台和系统的网页设计。
2. 参考文献
1. Takahashi-Ando, N., et al., A novel lactonohydrolase responsible for the detoxification of zearalenone: enzyme purification and gene cloning. Biochem J, 2002. 365(Pt 1): p. 1-6.2. Vekiru, E., et al., Cleavage of zearalenone by Trichosporon mycotoxinivorans to a novel nonestrogenic metabolite. Appl Environ Microbiol, 2010. 76(7): p. 2353-9.3. Tatusova, T., et al., NCBI prokaryotic genome annotation pipeline. Nucleic Acids Res, 2016. 44(14): p. 6614-24.4. Huntemann, M., et al., The standard operating procedure of the DOE-JGI Microbial Genome Annotation Pipeline (MGAP v.4). Stand Genomic Sci, 2015. 10: p. 86.5. Kanehisa, M., et al., KEGG as a reference resource for gene and protein annotation. Nucleic Acids Research, 2016. 44(D1): p. D457-D462.6. Roy, A., A. Kucukural, and Y. Zhang, I-TASSER: a unified platform for automated protein structure and function prediction. Nat Protoc, 2010. 5(4): p. 725-38.7. Carere, J., et al., The enzymatic detoxification of the mycotoxin deoxynivalenol: identification of DepA from the DON epimerization pathway. Microb Biotechnol, 2018. 11(6): p. 1106-1111.
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