1. 毕业设计（论文）的内容、要求、设计方案、规划等
前言：黄酮类化合物中糖苷键的组成对其生物活性影响很大。
研究表明，槲皮素和山奈酚经特定的糖基化后，生物利用度，抗病毒活性，防治阿尔兹海默症的能力均得到提高；在抗氧化、抗糖尿病、抗菌、抗慢性肾病等方面的活性有所降低。
因此，针对不同疾病开发药效更显著的黄酮苷元或糖苷药物意义重大。
2. 参考文献（不低于12篇）
1. 田季雨, 刘澎涛, 李斌: 银杏叶提取物化学成分及药理活性研究进展. 国外医学(中医中药分册) 2004(03):142-145.2. Xiao J, Chen T, Cao H: Flavonoid glycosylation and biological benefits. Biotechnology advances 2014.3. Kim S, Kim H, Choi S, Park K, Choi H, Lee M: Anti-oxidative and inhibitory activities on nitric oxide (NO) and prostaglandin E2 (COX-2) production of flavonoids from seeds of Prunus tomentosa Thunberg. Archives of pharmacal research 2008, 31(4):424-428.4. Akbay P, Basaran AA, Undeger U, Basaran N: In vitro immunomodulatory activity of flavonoid glycosides from Urtica dioica L. Phytotherapy Research 2003, 17(1):34-37.5. de Araujo ME, Moreira Franco YE, Alberto TG, Sobreiro MA, Conrado MA, Priolli DG, Frankland Sawaya AC, Ruiz AL, de Carvalho JE, de Oliveira Carvalho P: Enzymatic de-glycosylation of rutin improves its antioxidant and antiproliferative activities. Food chemistry 2013, 141(1):266-273.6. Westlake DWS, Talbot G, Blakley ER, Simpson FJ: MICROBIAL DECOMPOSITION OF RUTIN. Canadian Journal of Microbiology 1959, 5(6):621-629.7. Narikawa T, Shinoyama H, Fujii T: A beta-rutinosidase from Penicillium rugulosum IFO 7242 that is a peculiar flavonoid glycosidase. Bioscience, biotechnology, and biochemistry 2000, 64(6):1317-1319.8. Hendson M., Hildebrand D.C., Schroth M.N. Distribution among Pseudomonads of sequences homologous to the rutin glycosidase and beta-glucosidase genes of Pseudomonas viridiflava. Mol Plant Pathol 1992, 82:1230-1233.9. Xiao J, Muzashvili TS, Georgiev MI: Advances in the biotechnological glycosylation of valuable flavonoids. Biotechnology advances 2014, 32(6):1145-1156.10. Weignerova L, Marhol P, Gerstorferova D, Kren V: Preparatory production of quercetin-3-beta-D-glucopyranoside using alkali-tolerant thermostable alpha-L-rhamnosidase from Aspergillus terreus. Bioresource technology 2012, 115:222-227.11. Krisch J, Bencsik O, Papp T, Vagvolgyi C, Tako M: Characterization of a beta-glucosidase with transgalactosylation capacity from the zygomycete Rhizomucor miehei. Bioresource technology 2012, 114:555-560.12. Shimoda K, Sato N, Kobayashi T, Hamada H: Glycosylation of daidzein by the Eucalyptus cell cultures. Phytochemistry 2008, 69(12):2303-2306.13. Huang W, Ochiai H, Zhang X, Wang LX: Introducing N-glycans into natural products through a chemoenzymatic approach. Carbohydrate research 2008, 343(17):2903-2913.14. 吴薛明, 许婷婷, 储建林, 何冰芳: 黄酮类化合物酶法糖基化修饰的研究进展. 中国天然药物 2010(05):389-400.
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