1. 毕业设计（论文）的内容和要求
一、内容：1． 抗肿瘤药物盐酸柔红霉素为第一代蒽环类抗肿瘤抗生素，其作用机制酷似阿霉素。
作为一种周期非特异性化疗药，主要用于各种类型的急性白血病及恶性淋巴瘤，但由于其毒副作用，如易诱发不可逆性心脏毒性，因而限制了它的临床应用。
汉防己甲素，是从防己科植物粉防己块根中提取的一种双苄基异喹啉类生物碱，具有广泛的药理学作用，其抗肿瘤作用显著，当前研究显示其抗肿瘤机制包括诱导凋亡作用、化疗减毒增敏、逆转耐药及抗血管新生等。
2. 参考文献
[1] Sung SJ,Min SH,Cho KY et al.Effect of polyethleneglycol on gene delivery ofpolyethylenimine[J].Biol Pharm Bull,2003,26(4):492～500.[2] Jian Dai, Seyin Zou, Yuanyuan Pei,et al. Polyethylenimine-grafted copolymer of poly(L-lysine) and poly(ethylene glycol)for gene delivery [J]. Biomaterials, 2011, 32: 1694-1705.[3] Cheol-Hee Ahn, Su Young Chae,et al. Synthesis of biodegradable multi-block copolymers of poly (L-lysine) and poly (ethylene glycol) as a non-viral gene carrier [J]. Journal of Controlled Release, 2004, 97:567 574.[4] 胡海梅,张璇,潘仕荣.聚乙二醇-聚左旋赖氨酸共聚物生物降解性的研究[J].中国药房,2011,9: 814-817.[5] 唐明青,刁勇许,瑞安. 以壳聚糖为载体的口服基因药物[J].中国生化药物杂志, 2009, 30(2): 139-140.[6] Kurtoglu Y E, M ishra M K, Kannan S, et al. Drug release characteristics of PAMAM dendrimer drug conjugates with different linkers [J]. Int J Pharm, 2010, 384(1-2): 189-194.[7] JEONG J H, PARK T G. Poly(L-lysine)-g-poly(D,L-lactic-co-glycolic acid) micelles for low cytotoxic biodegradable gene delivery carriers [J]. Journal ofControl Release , 2002, 82(1): 159-166.[8] ALIABADI H M, BROCKS D R, LAVASANIFAR A. Polymeric micelles for the solubilization and delivery of cyclosporine A: Pharmacokinetics and biodistribution [J]. Biomaterials, 2005, 45(2): 82-89.[9] 陈大为,鄢璐,乔明曦.多西他赛pH敏感嵌段共聚物胶束的制备[J].药学学报，2008, 43 (10):1066 1070.[10]Ji Won Park, Hyejung Mok, Tae Gwan Park. Physical adsorption of PEG grafted and blocked poly-L-lysine copolymers on adenovirus surface for enhanced gene transduction [J]. Journal of Controlled Release,2010,142:238-244.
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