1. 毕业设计（论文）的内容和要求
1.内容在试验过程中，制定出一套试验方案，也就是具体步骤，即：1、动物给药造模2、动物模型验证3、机制研究4、数据处理。
本实验以雄性C57BL/6J小鼠为研究对象，探讨虫草多糖对小鼠糖尿病肾病的保护作用，并研究其作用机制。
2.要求掌握文献查阅的一般方法，学会使用计算机在中国期刊网，维普数据库，超星数字图书馆，Elsevier电子期刊，Pub Med，SCI等检索资源上查阅关于糖尿病肾病以及虫草多糖药理活性的相关文献。
2. 参考文献
1. Xue H, Li P, Luo Y, Wu C, Liu Y, Qin X, et al. Salidroside stimulates the Sirt1/PGC-1α axis and ameliorates diabetic nephropathy in mice. Phytomedicine. 2019;54:240-7.2. Xu HL, Wang XT, Cheng Y, Zhao JG, Zhou YJ, Yang JJ, et al. Ursolic acid improves diabetic nephropathy via suppression of oxidative stress and inflammation in streptozotocin-induced rats. Biomed Pharmacother. 2018;105:915-21.3. Xin R, Sun X, Wang Z, Yuan W, Jiang W, Wang L, et al. Apocynin inhibited NLRP3/XIAP signalling to alleviate renal fibrotic injury in rat diabetic nephropathy. Biomedicine 106:1325-31.4. Sharma D, Gondaliya P, Tiwari V, Kalia K. Kaempferol attenuates diabetic nephropathy by inhibiting RhoA/Rho-kinase mediated inflammatory signalling. Biomedicine 109:1610-9.5. Sharma D, Bhattacharya P, Kalia K, Tiwari V. Diabetic nephropathy: New insights into established therapeutic paradigms and novel molecular targets. Diabetes Research and Clinical Practice. 2017;128:91-108.6. Liu Y, Ye J, Cao Y, Zhang R, Wang Y, Zhang S, et al. Silibinin ameliorates diabetic nephropathy via improving diabetic condition in the mice. European Journal of Pharmacology. 2019;845:24-31.7. Zhang H, Zhang S, Wang L, Liu X, Wu Y. Chitooligosaccharide guanidine inhibits high glucose-induced activation of DAG/PKC pathway by regulating expression of GLUT2 in type 2 diabetic nephropathy rats. Journal of Functional Foods. 2018;41:41-7.8. Zhang C, Li Q, Lai S, Yang L, Shi G, Wang Q, et al. Attenuation of diabetic nephropathy by Sanziguben Granule inhibiting EMT through Nrf2-mediated anti-oxidative effects in streptozotocin (STZ)-induced diabetic rats. Journal of Ethnopharmacology. 2017;205:207-16.9. Li J, Bao L, Zha D, Zhang L, Gao P, Zhang J, et al. Oridonin protects against the inflammatory response in diabetic nephropathy by inhibiting the TLR4/p38-MAPK and TLR4/NF-κB signaling pathways. International Immunopharmacology. 2018;55:9-19.
以上是毕业论文任务书，课题毕业论文、开题报告、外文翻译、程序设计、图纸设计等资料可联系客服协助查找。
