锝-99m标记的靶向胰腺癌功能化聚乙烯亚胺/吉西他滨络合物的制备及其诊疗研究任务书

 2021-10-21 17:19:29

1. 毕业设计（论文）的内容和要求

1．文献查阅掌握文献查阅的一般方法，学会使用计算机在中国期刊网，维普数据库，超星数字图书馆，Elsevier、NCBI电子期刊，Springer Link全文电子期刊，pubmed等检索资源上查阅关于锝-99m以及聚乙烯亚胺/吉西他滨络合物的相关文献。

2．文献阅读及综述阅读与课题相关的外文及中文文献，了解国内外的研究动态，撰写文献综述。

3．明确实验任务，拟定实验方案根据所查阅文献的内容，确定实验内容及方案，拟定科学可行的研究计划。

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2. 参考文献

1） Khan, S., Setua, S., et al. (2019). "Superparamagnetic iron oxide nanoparticles of curcumin enhance gemcitabine therapeutic response in pancreatic cancer." Biomaterials 208, 83-97.2） Zhu, J. Y., L. F. Zheng, et al. (2014). "Targeted cancer theranostics using alpha-tocopheryl succinate-conjugated multifunctional dendrimer-entrapped gold nanoparticles." Biomaterials 35(26): 7635-7646.3） Chen, C., Zhou, B. Q., et al. (2016). "Branched polyethyleneimine modified with hyaluronic acid via a PEG spacer for targeted anticancer drug delivery." RSC Advances, 6, 9232-9239.4） Zhu, J. Y., Wang, G. Y., et al. (2018). "Multifunctional dendrimer-entrapped gold nanoparticles conjugated with doxorubicin for pH-responsive drug delivery and targeted CT imaging." Langmuir, 34 (41): 12428-12435.5） Zhu, J. Y., Xiong, Z. J., et al. (2015). "Encapsulation of doxorubicin within multifunctional gadolinium-loaded dendrimer nanocomplexes for targeted theranostics of cancer cells." RSC Advances, 5(38): 30286-30296.6） Zhou, B. Q., Zhao, L. Z, et al. (2017). "A multifunctional polyethylenimine-based nanoplatform for targeted anticancer drug delivery to tumors in vivo." J. Mater. Chem. B, 5, 1542-1550.7） Branco de Barros, A. L., S. F. de Andrade, et al. (2013). "Radiolabeling of low molecular weight-galactose-based glycodendrimer with technetium-99m and biodistribution studies." Journal of Radioanalytical and Nuclear Chemistry 298(1): 605-609.8） Kovacs, L., M. Tassano, et al. (2014). "Labeling polyamidoamine (PAMAM) dendrimers with technetium-99m via hydrazinonicotinamide (HYNIC)." Current radiopharmaceuticals 7(2): 115-122.9） Song, M., Z. Guo, et al. (2017). "Synthesis and preliminary evaluation of a Tc-99m-labeled folate-PAMAM dendrimer for FR imaging." Chemical Biology Drug Design 89(5): 755-761.10） Cheng, Y. J., J. Y. Zhu, et al. (2016). "131I-labeled multifunctional dendrimers modified with BmK CT for targeted SPECT imaging and radiotherapy of gliomas." Nanomedicine 11(10): 1253-1266.

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