125I标记的功能化聚乙烯亚胺负载丹酚酸A用于治疗黄斑区视网膜慢性疾病任务书

 2021-10-21 17:19:50

1. 毕业设计（论文）的内容和要求

1．文献查阅掌握文献查阅的一般方法，学会使用计算机在中国期刊网，维普数据库，超星数字图书馆，Elsevier、NCBI电子期刊，Springer Link全文电子期刊，pubmed等检索资源上查阅关于丹酚酸A以及聚乙烯亚胺载药复合材料的相关文献。

2．文献阅读及综述阅读与课题相关的外文及中文文献，了解国内外的研究动态，撰写文献综述。

3．明确实验任务，拟定实验方案根据所查阅文献的内容，确定实验内容及方案，拟定科学可行的研究计划。

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2. 参考文献

1） Mao, K., Shu, W., et al. (2017). "Salvianolic acid a protects retinal pigment epithelium from OX-LDL-induced inflammation in an age-related macular degeneration model." Discovery medicine 23(125): 129-148.2） Zhang, H., Liu, Y. Y., et al. (2014). "Salvianolic acid A protects RPE cells against oxidative stress through activation of Nrf2/HO-1 signaling." Free Radical Biology and Medicine 69, 219-228.3） Zhu, J. Y., L. Z. Zhao, et al. (2015). "Radionuclide 131I-labeled multifunctional dendrimers for targeted SPECT imaging and radiotherapy of tumors." Nanoscale 7(43): 18169-18178.4） Zhu, J. Y., L. F. Zheng, et al. (2014). "Targeted cancer theranostics using alpha-tocopheryl succinate-conjugated multifunctional dendrimer-entrapped gold nanoparticles." Biomaterials 35(26): 7635-7646.5） Cheng, Y. J., J. Y. Zhu, et al. (2016). "131I-labeled multifunctional dendrimers modified with BmK CT for targeted SPECT imaging and radiotherapy of gliomas." Nanomedicine 11(10): 1253-1266.6） Zhou, B. Q., Zhao, L. Z, et al. (2017). "A multifunctional polyethylenimine-based nanoplatform for targeted anticancer drug delivery to tumors in vivo." J. Mater. Chem. B, 5, 1542-1550.7） Zhu, J. Y., Wang, G. Y., et al. (2018). "Multifunctional dendrimer-entrapped gold nanoparticles conjugated with doxorubicin for pH-responsive drug delivery and targeted CT imaging." Langmuir, 34 (41): 12428-12435.8） Zhu, J. Y., Xiong, Z. J., et al. (2015). "Encapsulation of doxorubicin within multifunctional gadolinium-loaded dendrimer nanocomplexes for targeted theranostics of cancer cells." RSC Advances, 5(38): 30286-30296.9） Zhu, J. Y., L. F. Zheng, et al. (2014). "Targeted cancer theranostics using alpha-tocopheryl succinate-conjugated multifunctional dendrimer-entrapped gold nanoparticles." Biomaterials 35(26): 7635-7646.10） Chen, C., Zhou, B. Q., et al. (2016). "Branched polyethyleneimine modified with hyaluronic acid via a PEG spacer for targeted anticancer drug delivery." RSC Advances, 6, 9232-9239.

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