1. 毕业设计（论文）的内容和要求
课题简介脂肪酶是一种特殊的酯键水解界面酶，由于其结构稳定性、良好的溶剂耐受性以及高的立体选择性等特点，被普遍应用于不对称手性化合物的拆分中。
近年来，手性药物在世界销售市场占据越来越多的比例(手性药物占研发新药的比例为 68%以上）。
脂肪酶反应条件温和，反应产物纯度高，副产物少，具有高度的立体选择性，产物的光学纯度高，具有很强的可操作性。
2. 参考文献
1. Vieira GAB, Arau′jo DMF, de Lemos TLG, de Mattos MC,de Oliveira MCFO, Melo VMM, de Gonzalo G, GotorFerna′ndex V, Gotor V (2010) Candida tropicalis CE017: a new Brazilian enzymatic source for the bioreduction of aromatic prochiral ketones. J Braz Chem Soc 21:15091516.2. Vitale P, Perna FM, Agrimi G, Pisano I, Mirizzi F, Capobianco RV, Capriati V (2018) Whole-cell biocatalyst for chemoenzymatic total synthesis of rivastigmine. Catalysts 8(2):55.3. Sikora A, Cheminiak-Dudkiewicz D, Ziegler-Borowska M, Marsza MP (2017) Enantioseparation of (RS)-atenolol with the use of lipases immobilized onto new-synthesized magnetic nanoparticles. Tetrahedron Asymmet 28(2):374380.4. Novel method to investigate the interaction force between etoposide and APTES-functionalized Fe3O4@ nSiO2@ mSiO2nanocarrier for drug loading and release processes. J Phys Chem C 119(8):43794386.5. One-step antibody immobilization-based rapid and highly-sensitive sandwich ELISA procedure for potentialin vitro diagnostics. Sci Rep 4:4407.6. Amine modification of nonporous silica nanoparticles reduces inflammatory response following intratracheal instillation in murine lungs. Toxicol Lett 241:207215.7. Peixoto AF, Fernandes AC, Pereira C, Pires J, Freire C (2016) Physicochemical characterization of organosilylated halloysite clay nanotubes. Microporous Mesoporous Mater 219:145154.8. Saengdee P, Chaisriratanakul W, Bunjongpru W, Sripumkhai W, Srisuwan A, Jeamsaksiri W, Hruanun C, Poyai A, Promptmas C (2015) Surface modification of silicon dioxide, silicon nitride and titanium oxynitride for lactate dehydrogenase immobilization. Biosens Bioelectron 67:134138.9. Donadelli JA, Einschlag FSG, Laurenti E, Magnacca G, Carlos L (2018) Soybean peroxidase immobilized onto silica-coated superparamagnetic iron oxide nanoparticles: effect of silica layer on the enzymatic activity. Colloids Surf B 161:654661.
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