全文总字数：3181字
1. 毕业设计（论文）的内容和要求
对C57BL/6小鼠腹腔注射对乙酰氨基酚，建立肝损伤模型，对模型C57BL/6小鼠灌胃给药柠檬苦素进行治疗，观察模型C57BL/6小鼠活动状态的变化，考察体内效果。
摘除模型C57BL/6小鼠肝器官进行H Tacke, F.; Koch, A.; Trautwein, C., Liver - guardian, modifier and target of sepsis. Nature Reviews Gastroenterology Auzinger, G.; Dhawan, A.; Wendon, J., Acute liver failure. Lancet 2010, 376 (9736), 190-201.3. Wang, C.; Xia, Y.; Zheng, Y.; Dai, W.; Wang, F.; Chen, K.; Li, J.; Li, S.; Zhu, R.; Yang, J.; Yin, Q.; Zhang, H.; Wang, J.; Lu, J.; Zhou, Y.; Guo, C., Protective effects of N-acetylcysteine in concanavalin A-induced hepatitis in mice. Mediators Inflamm 2015, 2015, 189785.4. Farag, M. M.; Mohamed, M. B.; Youssef, E. A., Assessment of hepatic function, oxidant/antioxidant status, and histopathological changes in rats treated with atorvastatin: Effect of dose and acute intoxication with acetaminophen. Human Evans, L. E.; Alhazzani, W.; Levy, M. M.; Antonelli, M.; Ferrer, R.; Kumar, A.; Sevransky, J. E.; Sprung, C. L.; Nunnally, M. E.; Rochwerg, B.; Rubenfeld, G. D.; Angus, D. C.; Annane, D.; Beale, R. J.; Bellinghan, G. J.; Bernard, G. R.; Chiche, J. D.; Coopersmith, C.; De Backer, D. P.; French, C. J.; Fujishima, S.; Gerlach, H.; Hidalgo, J. L.; Hollenberg, S. M.; Jones, A. E.; Karnad, D. R.; Kleinpell, R. M.; Koh, Y.; Lisboa, T. C.; Machado, F. R.; Marini, J. J.; Marshall, J. C.; Mazuski, J. E.; McIntyre, L. A.; McLean, A. S.; Mehta, S.; Moreno, R. P.; Myburgh, J.; Navalesi, P.; Nishida, O.; Osborn, T. M.; Perner, A.; Plunkett, C. M.; Ranieri, M.; Schorr, C. A.; Seckel, M. A.; Seymour, C. W.; Shieh, L.; Shukri, K. A.; Simpson, S. Q.; Singer, M.; Thompson, B. T.; Townsend, S. R.; Van der Poll, T.; Vincent, J. L.; Wiersinga, W. J.; Zimmerman, J. L.; Dellinger, R. P., Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock: 2016. Intensive Care Medicine 2017, 43 (3), 304-377.6. Lv, H.; Qi, Z.; Wang, S.; Feng, H.; Deng, X.; Ci, X., Asiatic Acid Exhibits Anti-inflammatory and Antioxidant Activities against Lipopolysaccharide and d-Galactosamine-Induced Fulminant Hepatic Failure. Front Immunol 2017, 8, 785.7. Bauernfeind, F. G.; Horvath, G.; Stutz, A.; Alnemri, E. S.; MacDonald, K.; Speert, D.; Fernandes-Alnemri, T.; Wu, J.; Monks, B. G.; Fitzgerald, K. A.; Hornung, V.; Latz, E., Cutting edge: NF-kappaB activating pattern recognition and cytokine receptors license NLRP3 inflammasome activation by regulating NLRP3 expression. J Immunol 2009, 183 (2), 787-91.8. Szabo, G.; Bala, S.; Petrasek, J.; Gattu, A., Gut-Liver Axis and Sensing Microbes. Digestive Diseases 2010, 28 (6), 737-744.9. Hotchkiss, R. S.; Sherwood, E. R., Immunology. Getting sepsis therapy right. Science 2015, 347 (6227), 1201-2.10. Ahn, H.; Kang, S. G.; Yoon, S. I.; Kim, P. H.; Kim, D.; Lee, G. S., Poly-gamma-glutamic acid from Bacillus subtilis upregulates pro-inflammatory cytokines while inhibiting NLRP3, NLRC4 and AIM2 inflammasome activation. Cellular Molecular Immunology 2018, 15 (2), 111-119.
4. 毕业设计（论文）计划
起讫日期 设计（论文）各阶段工作内容2021.02 确定毕业设计课题及相关资料的检索 2021.02 完成开题报告 2021.03 实验方案的确定及实验条件的优化 2021.04 实验阶段 2021.05 各项实验数据处理 2021.06 毕业论文的撰写，制作答辩PPT 2021.06 在导师指导下修改论文，完成答辩
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