1. 毕业设计（论文）的内容和要求
{title}对C57BL/6小鼠腹腔注射对乙酰氨基酚，建立肝损伤模型，对模型C57BL/6小鼠灌胃给药柠檬苦素进行治疗，观察模型C57BL/6小鼠活动状态的变化，考察体内效果。
摘除模型C57BL/6小鼠肝器官进行H1444.[2] C. Wang, Y. Xia, Y. Zheng, W. Dai, F. Wang, K. Chen, J. Li, S. Li, R. Zhu, J. Yang, Q. Yin, H. Zhang, J. Wang, J. Lu, Y. Zhou, C. Guo, Protective effects of N-acetylcysteine in concanavalin A-induced hepatitis in mice, Mediators Inflamm. 2015(2015) 189785. [3]Watkins PB, Merz M, Avigan MI, Kaplowitz N, Regev A, Senior JR. The clinical liver safety assessment best practices workshop: rationale, goals, accomplishments and the future. Drug Saf 2014;37(Suppl 1):S1-S7. [4]Antoine DJ, Jenkins RE, Dear JW, Williams DP, McGill MR, Sharpe MR, et al. Molecular forms of HMGB1 and keratin-18 as mechanistic biomarkers for mode of cell death and prognosis during clinical acetaminophen hepatotoxicity. J Hepatol 2012;56: 1070-1079. [5]Ostapowicz G, Fontana RJ, Schiodt FV, Larson A, Davern TJ, Han SH, et al. Results of a prospective study of acute liver failure at 17 tertiary care centers in the United States. Ann Intern Med 2002;137:947-954.[6]Lee WM. Acetaminophen and the U.S. acute liver failure study group: lowering the risks of hepatic failure. Hepatology. 2004; 40(1):69. [PubMed: 15239078][7]W. Klein-Schwartz, S. Doyon, Intravenous acetylcysteine for the treatment of acetaminophen overdose, Expert Opin. Pharmacother. 12 (2011) 119130.[8]V.S. Bebarta, L. Kao, B. Froberq, R.F. Clark, E. Lavonas, M. Qi, et al., A multicenter comparison of the safety of oral versus intravenous acetylcysteine for treatment of acetaminophen overdose, Clin. Toxicol. (Phila) 48 (2010) 424430.[9]Si Qin, Chenghao Lv, Qingshan Wang, Zhibing Zheng, Xi Sun, Minyi Tang, Fangming Deng, Extraction, identification, and antioxidant property evaluation of limonin from pummelo seeds, Animal Nutrition. 4 (2018) 281e287.[10]Tian, Q.; Miller, E. G.; Ahmad, H.; Tang, L.; Patil, B. S. Nutr. Cancer 2001, 40, 180.
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