1. 毕业设计（论文）的内容和要求
Remdesivir（瑞德西韦）是美国吉利德科学公司的在研药品，是一种核苷类似物，具有抗病毒活性。
在体外和动物模型中，Remdesivir已经证实了对非典型性肺炎（SARS）和中东呼吸综合征（MERS）的病毒病原体均有活性，最近的试验研究也表明在抗新型冠状病毒（Covid-19）时初步展现出较好的疗效，但其有效性还要经过大规模临床试验才能得到进一步验证。
本论文的主要内容是通过文献调研和最新的网上公开数据的整理和总结，合理评估Remdesivir在治疗新型冠状病毒（Covid-19）感染临床实验中的安全性和有效性，为临床安全合理用药提供科学依据。
2. 参考文献
1.Yin W, Mao C, Luan X, et al. Structural basis for inhibition of the RNA-dependent RNA polymerase from SARS-CoV-2 by remdesivir[J]. Science, 2020.2.Warren T K, Jordan R, Lo M K, et al. Therapeutic efficacy of the small molecule GS-5734 against Ebola virus in rhesus monkeys[J]. Nature, 2016, 531(7594): 381-385.3.Siegel D, Hui H C, Doerffler E, et al. Discovery and Synthesis of a Phosphoramidate Prodrug of a Pyrrolo [2, 1-f][triazin-4-amino] Adenine C-Nucleoside (GS-5734) for the Treatment of Ebola and Emerging Viruses[J]. 2017,60(5):1648-16614.Agostini M L, Andres E L, Sims A C, et al. Coronavirus susceptibility to the antiviral remdesivir (GS-5734) is mediated by the viral polymerase and the proofreading exoribonuclease[J]. MBio, 2018, 9(2):e00221-185.Sheahan T P, Sims A C, Graham R L, et al. Broad-spectrum antiviral GS-5734 inhibits both epidemic and zoonotic coronaviruses[J]. Science translational medicine, 2017, 9(396):eaal36536.Gordon C J, Tchesnokov E P, Feng J Y, et al. The antiviral compound remdesivir potently inhibits RNA-dependent RNA polymerase from Middle East respiratory syndrome coronavirus[J]. Journal of Biological Chemistry, 2020, 295(15): 4773-4779.7.Lo M K, Jordan R, Arvey A, et al. GS-5734 and its parent nucleoside analog inhibit Filo-, Pneumo-, and Paramyxoviruses[J]. Scientific reports, 2017, 7:433958.Yethindra V. Role of GS-5734 (Remdesivir) in inhibiting SARS-CoV and MERS-CoV: The expected role of GS-5734 (Remdesivir) in COVID-19 (2019-nCoV)-VYTR hypothesis[J]. International Journal of Research in Pharmaceutical Sciences, 2020, 11(SPL1): 1-6.9.Wang M, Cao R, Zhang L, et al. Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro[J]. Cell research, 2020, 30(3): 269-271.10.Tchesnokov E P, Feng J Y, Porter D P, et al. Mechanism of inhibition of Ebola virus RNA-dependent RNA polymerase by remdesivir[J]. Viruses, 2019, 11(4):32611.Li Z, Wang X, Cao D, et al. Rapid review for the anti-coronavirus effect of remdesivir[J]. Drug Discoveries Therapeutics, 2020, 14(2): 73-76.12.Wang Y, Zhang D, Du G, et al. Remdesivir in adults with severe COVID-19: a randomised, double-blind, placebo-controlled, multicentre trial[J]. The Lancet, 2020.13.Grein J, Ohmagari N, Shin D, et al. Compassionate use of remdesivir for patients with severe Covid-19[J]. New England Journal of Medicine, 2020.14.Holshue M L, DeBolt C, Lindquist S, et al. First case of 2019 novel coronavirus in the United States[J]. New England Journal of Medicine, 2020.15.De Wit E, Feldmann F, Cronin J, et al. Prophylactic and therapeutic remdesivir (GS-5734) treatment in the rhesus macaque model of MERS-CoV infection[J]. Proceedings of the National Academy of Sciences, 2020, 117(12): 6771-6776.
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