1. 毕业设计（论文）的内容和要求
介孔修饰上转换发光材料拥有许多优点,例如低毒性、高化学稳定性、优异的光稳定性、窄带发射、长的发光寿命另外近红外激光作为其激发光源带来了许多优势,例如较深的光穿透深度,对生物组织几乎无损伤、生物组织不会发光无背景荧光等这些特征使它们可望成为新一代生物发光标记。
介孔修饰上转换发光纳米材料生物应用的前提是制备水溶性的、表面有活性基团例如羧酸、氨基、和硫醇等。
用于生物发光标记的前提是其尺寸较小并形貌可控在水溶液中具有较高的上转换发光效率表面有活性基团，并且具有水溶性、生物兼容性好。
2. 参考文献
[1] Wang C, Cheng L, Liu Y, Wang X, Ma X, Deng Z, et al. Imaging-guided pHsensitive photodynamic therapy using charge reversible upconversion nanoparticles under near-infrared light. Adv Funct Mater 2013;23:3077-86.[2] Cheng L, Yang K, Li Y, Chen J, Wang C, Shao M, et al. Facile preparation of multifunctional upconversion nanoprobes for multimodal imaging and dualtargeted photothermal therapy. Angew Chem Int Ed 2011;50:7385-90.[3] Jayakumar MKG, Idris NM, Zhang Y. Remote activation of biomolecules in deep tissues using near-infrared-to-UV upconversion nanotransducers. Proc Natl Acad Sci U S A 2012;109:8483-8.[4] Liu Z, Ju E, Liu J, Du Y, Li Z, Yuan Q, et al. Direct visualization of gastrointestinal tract with lanthanide-doped BaYbF5 upconversion nanoprobes. Biomaterials 2013;34:7444-52.[5] Min Y, Li J, Liu F, Yeow EKL, Xing B. Near-infrared light-mediated photoactivation of a platinum antitumor prodrug and simultaneous cellular apoptosis imaging by upconversion-luminescent nanoparticles. Angew Chem Int Ed 2014;53:1012-6.[6] Zhang C, Zhou H-P, Liao L-Y, Feng W, Sun W, Li Z-X, et al. Luminescence modulation of ordered upconversion nanopatterns by a photochromic diarylethene: rewritable optical storage with nondestructive readout. Adv Mater 2010;22:633-7.[7] Feng W, Han C, Li F. Upconversion-nanophosphor-based functional nanocomposites. Adv Mater 2013;25:5287-303.[8] Xie X, Gao N, Deng R, Sun Q, Xu Q-H, Liu X. Mechanistic investigation of photon upconversion in Nd3t-sensitized coreeshell nanoparticles. J Am Chem Soc 2013;135:12608-11.[9] Wang F, Deng R, Wang J, Wang Q, Han Y, Zhu H, et al. Tuning upconversion through energy migration in coreeshell nanoparticles. Nat Mater 2011;10: 968-73.[10] Huang P, Zheng W, Zhou S, Tu D, Chen Z, Zhu H, et al. Lanthanide-doped LiLuF4 upconversion nanoprobes for the detection of disease biomarkers. Angew Chem Int Ed 2014;53:1252-7.[11] Liu Y, Chen M, Cao T, Sun Y, Li C, Liu Q, et al. A cyanine-modified nanosystem for in vivo upconversion luminescence bioimaging of methylmercury. J Am Chem Soc 2013;135:9869-76.[12] Li C, Liu J, Alonso S, Li F, Zhang Y. Upconversion nanoparticles for sensitive and in-depth detection of Cuions. Nanoscale 2012;4:6065e71.[13] Haase M, Schafer H. Upconverting nanoparticles. Angew Chem Int Ed2011;50:5808-29.[14] Chen Z, Zhou L, Bing W, Zhang Z, Li Z, Ren J, et al. Light controlled reversible inversion of nanophosphor-stabilized pickering emulsions for biphasic enantioselective biocatalysis. J Am Chem Soc 2014;136:7498-504.[15] Liu J, Bu W, Pan L, Shi J. NIR-triggered anticancer drug delivery by upconverting nanoparticles with integrated azobenzene-modified mesoporous silica. Angew Chem Int Ed 2013;52:4375-9.[16] Toyama H, Ye D, Ichise M, Liow JS, Cai L, Jacobowitz D, et al. PET imaging of brain with the beta-amyloid probe, [11C]6-OH-BTA-1, in a transgenic mouse model of Alzheimer's disease. Eur. J. Nucl. Med. Mol. Imaging 2005;32:593-600.[17] Bottrill M, Nicholas LK, Long NJ. Lanthanides in magnetic resonance imaging. Chem. Soc. Rev. 2006;35:557-71.
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