全文总字数：6152字
1. 毕业设计（论文）的内容和要求
三嗪类化合物是一类含氮杂环化合物，在化工染料、材料方面应用广泛，且是杀虫剂、除草剂中重要的组成结构。
近十年来发现其在抗炎、抗高血压、抑制血小板的生成及抑菌方 面也有着显著作用，因此是一类重要的医药中间体。
本课题即以1-甲基-1-苯肼和恶二唑酮在三价铑的催化作用下生成1，2，4-三嗪为模板反应探索该反应的普适性。
2. 实验内容和要求
1.条件优化通过对不同条件的筛选(诸如改变酸，添加剂等)从而得出1，2，4-三嗪产率最高的条件2.底物拓展通过在1-甲基-1-苯肼或恶二唑酮加入不同的取代基(给电子或吸电子或大位阻)来研究该反应的普适性3.机理探索通过动力学同位素试验等来探索反应的机理
3. 参考文献
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4. 毕业设计（论文）计划
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