1. 毕业设计（论文）的内容和要求
杂环化合物广泛存在于自然界中,在医药、农药、催化剂、发光材料、染料等领域中所起的作用日益显著。
含氧杂环特别是具有苯并吡喃酮结构的化合物,如异香豆素衍生物,是许多常见药物中的关键结构和活性单元。
由于其具有良好的生物活性,比如抗菌、消炎、抗癌、抑制蛋白酶和除草等,在人类生产生活中发挥着重要作用而备受关注。
2. 参考文献
[1]Ackermann L, Poepech J. Ruthenium-Catalyzed Oxidative C-H Bond Alkenylations in Water: Expedient Synthesis of Annulated Lactones. Organic Letters, 2011,12 (16):4153-4155.[2]Rama N, Iqbal R, Zamani K, et al. Synthesis of Antibacterial Isoeoumarins: Synthesis and Antibacterial Activity of 3-Alkylisocoumarins and (dl)-3 alkyl-3, 4-dihydroisoeoumarins. Journal of Indian Chemistry, 1998, 37: 365-369[3]Hussainm M, Rama N, Malik A. Synthesis of Some New 3-(Bronaophenyl) Isocoumarins and Their Conversion to (dl)-3, 4-Dihydroisocoumarins. Journal of Indian Chemistry, 2001, 40: 372-376[4]Powers J, Asgian J, Ekici D, James K, et al. Inhibitors of Serine, Cysteine, and Threonine Proteases. Chemical Reviews, 2002, 102: 4715-4722[5]Harper J, Hemmi K, Powers J, et al. Reaction of Serine Proteases with Substituted Isocoumarins: Discovery of 3, 4-Dichloroisocoumarin, a New General Mechanism Based Serine Protease Inhibitor. Biochemistry, 1985, 24:1831-1841 [6]Kam c, Fujikawa K, Powers J, et al. Mechanism Based Isocoumarin Inhibitors for Trypsin and Blood Coagulation Serine Proteases: Anticoagulants. Biochemistry, 1988, 27, 2547-2557[7]Kerrigan J, Kam C, Plaskon R, et al. Mechanism-Based Isocoumarin Inhibitors for Blood Coagulation Serine Proteases, Effect of the 7-Substituent in 7-Amino-4-chloro-3-(isothioureidoalkoxy) Isocoumarins on Inhibitory and Anticoagulant Potency. Medicinal Chemistry, 1994, 37: 1298-1306[8]Quelever G, Bihel F, Lelouard H, et al. Sythesis of 3- Alkoxy-7-amino-4-chloro-isocoumarinDerivatives as New -Amyloid Peptide Production Inhibitors and Their Actvities on Various Classes of Protease. Bioorganic Medicinal Chemistry Letters, 2003, 11: 3141-3152[9]Ohsono M, Kumagai H, Masuda T, et al. A Novel Antitumor Substance. Journal of Antibiotics, 1 990, 43: 1505-1507[10] Nakashima T, Hirano S, Agata N, et al. Inhibition of Angiogenesis by a New Isocoumarin, NM-3. The Journal of Antibiotics, 1999, 52: 426-428
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