代谢工程改造毕赤酵母合成2-苯乙醇的研究任务书

 2021-10-23 20:18:30

1. 毕业设计(论文)的内容和要求

1.文献查阅掌握文献查阅,使用网络资源如中国期刊网、维普数据库、超星数字图书馆、Elsevier电子期刊、Springer Link全文电子期刊等检索资源,查阅关于苯丙氨酸的相关文献。

2.文献阅读及综述阅读与课题相关的外文与中文文献,了解国内外的研究动态,撰写文献综述。

3.明确实验任务,拟定实验方案根据所查阅文献的内容,确定实验内容及方案,拟定科学可行的研究计划。

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2. 参考文献

[1] Scognamiglio J, Jones L, Letizia CS. Fragrance material review on phenylethyl alcohol. Food Chem Toxicol. 2012;50:S224朣239.[2] Bia砮cka-Florjanczyk E, Krzyczkowska J, Stolarzewicz I, et al. Synthesis of 2-phenylethyl acetate in the presence of Yarrowia lipolytica KKP 379 biomass. J Mol Cata B Enzym. 2012;74:241?45.[3] C竐lik D, Bayraktar E, Mehmetoglu Biotransformation of 2-phenylethanol to phenylacetaldehyde in a two-phase fed-batch system. Biochem Eng J. 2004;17:5?3.[4] Rusanov K, Kovacheva N, Vosman B, et al.Microsatellite analysis of Rosa damascena Mill. accessions reveals genetic similarity between genotypes used for rose oil production and old Damask rose varieties. Theor Appl Genet. 2005;111:804?09.[5] Arguel H, Aubert C, Baumann S. Optimization of the analysis of flavor volatile compounds by liquid杔iquid microextraction (LLME). Application to the aroma analysis of melons, peaches, grapes, strawberries,and tomatoes. J Agric Food Chem. 2005;53:8881?896.[6] Horbowicz M, Wiczkowski W, Sawicki T, et al. Methyl jasmonate stimulates biosynthesis of 2-phenylethylamine, phenylacetic acid and 2-phenylethanol in seedlings of common buckwheat. Acta Biochim Pol. 2015;62:235?40.[7] Kovacheva N, Rusanov K, Atanassov I. Industrial cultivation of oil bearing rose and rose oil production in Bulgaria during 21century, directions and challenges Biotechnol Biotechnol Equip. 2010;24:1793?798.[8] Kim B, Cho BR, Hahn JS. Metabolic engineering of Saccharomyces cerevisiae for the production of 2- phenylethanol via Ehrlich pathway. Biotechnol Bioeng. 2014;111:115?25.[9] Bauer K, Garbe D, Surburg H. Common fragrance and flavor materials. Preparation, properties and uses. Fourth, Completely Revised Edition. 2nd ed. Weinheim: Wiley-VCH; 2001.[10] JianFeng M, Hong C. Production of b-Phenylethanol by bioconversion. Microbiology. 2005;32:114?18.[11] Kirm I, Medina F, Sueiras JE, et al. Hydrogenation of styrene oxide in the presence of supported platinum catalysts to produce 2-phenylethanol. J Mol Catal A Chem. 2007;261:98?03.[12] Carroll AL, Desai SH, Atsumi S. Microbial production of scent and flavor compounds. Curr Opin Biotechnol. 2016;37:8?5.[13] Etschmann MMW, Sell D, Schrader J. Medium optimization for the production of the aroma compound 2-phenylethanol using a genetic algorithm. J Mol Catal B Enzym. 2004;29:187?93.[14] Celinska E, Kubiak P, Bia 砤s W, et al. Yarrowia lipolytica: the novel and promising 2-phenylethanol producer. J Ind Microbiol Biotechnol. 2013;40:389?92.[15] Masuo S, Osada L, Zhou S, et al. Aspergillus oryzae pathways that convert phenylalanine into the flavor volatile 2-phenylethanol. Fungal Genet Biol. 2015;77: 22?0.

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