电催化芳环选择性卤代任务书

 2021-10-25 21:00:21

1. 毕业设计(论文)的内容和要求

随着传统化学及传统化学试剂带来的污染越来越严重,寻求更加绿色环保、经济安全的新颖化学手段或化学试剂受到了越来越多的重视。

电化学利用绿色的电能起到高效氧化还原的作用可替代传统的高污染、高危险性的氧化剂与还原剂。

本课题寻求以电催化的方法,寻找更加绿色的卤代试剂进行芳烃的选择性卤代,其在合成化学及药物化学中均具有重要的意义。

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2. 参考文献

1.Monnier, F., and Taillefer, M. (2009). Catalytic C-C, C-N, and C-O Ullmann-type coupling reactions. Angew. Chem. Int. Ed. 48, 6954-6971.2.Khan, F., Dlugosch, M., Liu, X., and Banwell, M. G. (2018). The palladium-catalyzed Ullmann cross-coupling reaction: A modern variant on a time-honored process. Accounts Chem. Res. 51, 1784-1795.3.Kouznetsov, V. V., and Mendez, L. Y. V. (2008). Recent developments in three-component Grignard-Barbier-type reactions. Synthesis-Stuttgart. 491-506.4.Terao, J., and Kambe, N. (2008). Cross-coupling reaction of alkyl halides with grignard reagents catalyzed by Ni, Pd, or Cu complexes with pi-Carbon Ligand(s). Accounts Chem. Res. 41, 1545-1554.5.Hernandes, M. Z., Cavalcanti, S. M. T., Moreira, D. R. M., De Azevedo, W. F., and Lima Leite, A. C. (2010). Halogen atoms in the modern medicinal chemistry: Hints for the drug design. Curr. Drug Targets 11, 303-314.6.Jeschke, P. (2010) The unique role of halogen substituents in the design of modern agrochemicals. Pest Manag. Sci. 66, 10-27.7. Xu, Z., Yang, Z., Liu, Y., Lu, Y., Chen, K., and Zhu, W. (2014). Halogen Bond: Its role beyond drug-target binding affinity for drug discovery and development. J. Chem. Inf. Model. 54, 69-78.

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