1. 毕业设计（论文）的内容、要求、设计方案、规划等
生物信息学是当前的热点研究课题，很多研究者对人类基因组、水稻基因组等常见的动植物进行研究，对于茯苓的基因组研究目前还未见报道，本课题拟下载整个植物基因组到本地计算机，并利用blast程序建立搜索引擎，实现本地化的数据库查询，为下一步的茯苓基因组研究打下基础。
2. 参考文献（不低于12篇）
1,Altschul, S.F., Gish, W., Miller, W., Myers, E.W. and Lipman, D.J. (1990) Basic local alignment search tool. J. Mol. Biol. 215, 403410.PubMed,ChemPort,Web of Science2,Altschul, S.F., Madden, T.L., Schffer, A.A., Zhang, J., Zhang, Z., Miller, W. and Lipman, D.J. (1997) Gapped BLAST and PSI-BLAST: a new generation of protein database search programs. Nucleic Acids Res. 25, 33893402.CrossRef,PubMed,ChemPort,Web of Science3,Smith, T.F. and Waterman, M.S. (1981) Identification of common molecular subsequences. J. Mol. Biol. 147, 195197.CrossRef,PubMed,ChemPort,Web of Science4,Needleman, S.B. and Wunsch, C.D. (1970) A general method applicable to the search for similarities in the amino acid sequences of two proteins. J. Mol. Biol. 48, 443453.CrossRef,PubMed,Web of Science5,Tomb, J.-F., White, O., Kerlavage, A.R., Clayton, R.A., Sutton, G.G., Fleischmann, R.D., Ketchum, K.A., Klenk, H.P., Gill, S., Dougherty, B.A., Nelson, K., Quackenbush, J., Zhou, L., Kirkness, E.F., Peterson, S., Loftus, B., Richardson, D., Dodson, R., Khalak, H.G., Glodek, A., McKenney, K., Fitzegerald, L.M., Lee, N., Adams, M.D., Hickey, E.K., Berg, D.E., Gocayne, J.D., Utterback, T.R., Peterson, J.D., Kelley, J.M., Cotton, M.D., Weidman, J.M., Fujii, C., Bowman, C., Watthey, L., Wallin, E., Hayes, W.S., Borodovsky, M., Karp, P.D., Smith, H.O., Fraser, C.M. and Venter, J.C. (1997) The complete genome sequence of the gastric pathogen Helicobacter pylori. Nature 388, 539547.CrossRef,PubMed,ChemPort,Web of Science6,Alm, R.A., Ling, L.-S.L., Moir, D.T., King, B.L., Brown, E.D., Doig, P.C., Smith, D.R., Noonan, B., Guild, B.C., deJonge, B.L., Carmel, G., Tummino, P.J., Caruso, A., Uria-Nickelsen, M., Mills, D.M., Ives, C., Gibson, R., Merberg, D., Mills, S.D., Jiang, Q., Taylor, D.E., Vovis, G.F. and Trust, T.J. (1999) Genomic sequence comparison of two unrelated isolates of the human gastric pathogen Helicobacter pylori. Nature 397, 176180.CrossRef,PubMed,Web of Science7,Henikoff, S. and Henikoff, J.G. (1992) Amino acid substitution matrices from protein blocks. Proc. Natl. Acad. Sci. USA, 89, 1091510919.CrossRef,PubMed,ChemPort,Web of Science8,Altschul, S.F. and Erickson, B.W. (1986) Optimal sequence alignment using affine gap costs. Bull. Math. Biol. 48, 603616.PubMed,ChemPort,Web of Science9,Karlin, S. and Altschul, S.F. (1990) Methods for assessing the statistical significance of molecular sequence features by using general scoring schemes. Proc. Natl. Acad. Sci. USA 87, 22642268.CrossRef,PubMed,Web of Science10,Wootton, J.C. and Federhen, S. (1993) Statistics of local complexity in amino acid sequences and sequence databases. Comput. Chem. 17, 149163.CrossRef11,Altschul, S.F. and Gish, W. (1996) Local alignment statistics. Methods Enzymol. 266, 460480.CrossRef,PubMed,ChemPort,Web of Science
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