全文总字数：3490字
1. 毕业设计（论文）的内容和要求
本课题研究基本的平面两相相分离问题，目的在于通过软件或者编程的方法进行简单的模拟。
研究中可以选择基本的分子作用势作为两相分子之间的相互作用，可以选择有限大平面，可以可视化第展现相分离的过程。
2. 实验内容和要求
本课题采用理论分析方法进行研究，无实验内容及要求。
3. 参考文献
1.Lin Yanxian, et al., Liquid-Liquid Phase Separation of Tau Driven by Hydrophobic Interaction Facilitates Fibrillization of Tau, Journal of Molecular Biology, Journal of Molecular Biology Volume 433, Issue 2. 2021 2.Omar Adame-Arana, Christoph A. Weber, Vasily Zaburdaev et al. Liquid Phase Separation Controlled by pH[J] Biophysical Journal, 2020 3.Babinchak W. Michael, Dumm Benjamin K., Venus Sarah et al. Small molecules as potent biphasic modulators of protein liquid-liquid phase separation[J] Nature Communications, 2020, 11(1)1.Brangwynne, C.P., et al., Germline P granules are liquid droplets thatlocalize by controlled dissolution/condensation. Science, 2009. 324(5935): p. 1729-32.4.相分离微成模模拟生物结构表面，刘一流，高见，许华平，王治强，张希，2009 年全国高分子学术论文报告会论文摘要集（上册）5.基于FLUENT 的紧凑型油水分离器性能模拟研究，王玉江，杨风斌， 李秀丽，陈建树，史仕荧，中国石油和化工标准与质量. 2020 年 13 期6.稀薄气体流动机理的分子动力学模拟与研究[D]，古君君.湖南:国防科技大学,20177. Han, T.W., et al., Cell-free formation of RNA granules: boundRNAs identify features and components of cellular assemblies. Cell, 2012. 149(4): p. 768-79.8. Kato, M., et al., Cell-free formation of RNA granules: lowcomplexity sequence domains form dynamic fibers within hydrogels. Cell,2012. 149(4): p. 753-67.9. Shin, Y., and Brangwynne, C.P. (2017). Liquid phase condensation in cell physiology and disease. Science357.10. Zeng, M., Chen, X., Guan, D., Xu, J., Wu, H., Tong, P., and Zhang, M. (2018). Reconstituted Postsynaptic Density as a Molecular Platform for Understanding Synapse Formation and Plasticity. Cell 174, https://doi.org/10.1016/j.cell.2018.06.047.11. de Vivo, L., Bellesi, M., Marshall, W., Bushong, E.A., Ellisman, M.H., Tononi, G., and Cirelli, C. (2017). Ultrastructural evidence for synaptic scaling across the wake/sleep cycle. Science355, 507-510.12.Kato, M. et al. Cellfree formation of RNA granules: low complexity sequence domains form dynamic fibers within hydrogels. Cell 149, 753767 (2012).13. Jiang, H. et al. Phase transition of spindleassociated protein regulate spindle apparatus assembly. Cell 163, 108122 (2015).14. Lin, Y., Protter, D. S. W., Rosen, M. K. Parker, R. Formation and maturation of phaseseparated liquid droplets by RNAbinding proteins. Mol. Cell 60, 208219 (2015).15. Pak, C. W. et al. Sequence determinants of intracellular phase separation by complex coacervation of a disordered protein. Mol. Cell 63, 7285 (2016).16. Crick, S. L., Jayaraman, M., Frieden, C., Wetzel, R. Pappu, R. V. Fluorescence correlation spectroscopy shows that monomeric polyglutamine molecules form collapsed structures in aqueous solutions. Proc. Natl Acad. Sci. USA 103, 1676416769 (2006).17. Crick, S. L., Ruff, K. M., Garai, K., Frieden, C. and Cterminal flanking sequences from exon 1 of huntingtin as modulators of polyglutamine aggregation. Proc. Natl Acad. Sci. USA 110, 2007520080 (2013).18. Das, R. K. Pappu, R. V. Conformations of intrinsically disordered proteins are influenced by linear sequence distributions of oppositely charged residues. Proc. Natl Acad. Sci. USA 110, 1339213397 (2013).
4. 毕业设计（论文）计划
2020.12.31-2021.01.09 明确论文任务、搜集相关资料2021.01.10-2021.02.20 文献调研及外文翻译、完成开题报告2021.02.21-2021.03.10 选定恰当的两相分子及分子间的相互作用势2021.03.11-2021.04.10 利用软件或者编程进行模拟2021.04.11-2021.05.10 撰写毕业论文初稿2021.05.11-2021.06.03 毕业论文修改及定稿2021.06.04-2021.06.12 毕业论文答辩
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